Genetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insect

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dc.contributor.author Hamilton, Phineas T.
dc.contributor.author Hodson, Christina N.
dc.contributor.author Curtis, Caitlin I.
dc.contributor.author Perlman, Steve
dc.date.accessioned 2019-09-18T22:13:20Z
dc.date.copyright 2018 en_US
dc.date.issued 2018
dc.identifier.citation Hamilton, P.T., Hodson, C.N., Curtis, C.I. & Perlman, S.J. (2018). Genetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insect. Current Biology, 28(23), 3864-3870.e4. https://doi.org/10.1016/j.cub.2018.10.035 en_US
dc.identifier.uri https://doi.org/10.1016/j.cub.2018.10.035
dc.identifier.uri http://hdl.handle.net/1828/11157
dc.description.abstract Diverse selfish genetic elements have evolved the ability to manipulate reproduction to increase their transmission, and this can result in highly distorted sex ratios [1]. Indeed, one of the major explanations for why sex determination systems are so dynamic is because they are shaped by ongoing coevolutionary arms races between sex-ratio-distorting elements and the rest of the genome [2]. Here, we use genetic crosses and genome analysis to describe an unusual sex ratio distortion with striking consequences on genome organization in a booklouse species, Liposcelis sp. (Insecta: Psocodea), in which two types of females coexist. Distorter females never produce sons but must mate with males (the sons of nondistorting females) to reproduce [3]. Although they are diploid and express the genes inherited from their fathers in somatic tissues, distorter females only ever transmit genes inherited from their mothers. As a result, distorter females have unusual chimeric genomes, with distorter-restricted chromosomes diverging from their nondistorting counterparts and exhibiting features of a giant non-recombining sex chromosome. The distorter-restricted genome has also acquired a gene from the bacterium Wolbachia, a well-known insect reproductive manipulator; we found that this gene has independently colonized the genomes of two other insect species with unusual reproductive systems, suggesting possible roles in sex ratio distortion in this remarkable genetic system. en_US
dc.description.sponsorship This work was funded by an Natural Sciences and Engineering Research Council (NSERC) Discovery Grant to S.J.P. S.J.P. also acknowledges support from the Canadian Institute for Advanced Research’s Integrated Microbial Biodiversity Program. We thank Compute Canada for access to computational resources that enabled this study and Jong Leong and David Minkley for method discussion and advice. P.T.H. is supported by a Canadian Institutes of Health Research (CIHR) postdoctoral fellowship. en_US
dc.language.iso en en_US
dc.publisher Current Biology en_US
dc.subject sex ratio en_US
dc.subject Wolbachia en_US
dc.subject paternal genome elimination en_US
dc.subject selfish genetic elements en_US
dc.subject genetic conflict en_US
dc.subject sex determination en_US
dc.subject lice en_US
dc.subject booklice en_US
dc.title Genetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insect en_US
dc.type Preprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US

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