Host-guest binding in water, salty water, and biofluids: general lessons for synthetic, bio-targeted molecular recognition

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dc.contributor.author Beatty, Meagan A.
dc.contributor.author Hof, Fraser
dc.date.accessioned 2020-09-24T14:51:56Z
dc.date.copyright 2020 en_US
dc.date.issued 2020-09-24
dc.identifier.uri http://hdl.handle.net/1828/12140
dc.description.abstract This is a tutorial review aimed at senior undergraduates, early graduate students, and researchers at any level who are new to aqueous host-guest chemistry. Synthetic molecular recognition systems are increasingly being used to solve applied problems in the life sciences, and bio-targeted host-guest chemistry has rapidly arisen as a major field of fundamental research. This tutorial review presents a set of fundamental lessons on how host-guest molecular recognition can be programmed in water. The review uses informative examples of aqueous host-guest chemistry organized around generalizable themes and lessons, building towards lessons focused on molecular recognition in salty solutions and biological fluids. It includes selected examples of macrocyclic host systems that work well, as well as common pitfalls and how to avoid them. The review closes with a survey of the most important recent advances, which involve host-guest chemistry in living cells and organisms. en_US
dc.description.sponsorship NSERC Discovery Grant RGPIN-2019-04806 en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ *
dc.subject Host-guest chemistry en_US
dc.subject Molecular recognition en_US
dc.subject Water en_US
dc.subject Salt effects en_US
dc.subject Self-assembly en_US
dc.subject Macrocycles en_US
dc.subject Hydrophobic effect en_US
dc.title Host-guest binding in water, salty water, and biofluids: general lessons for synthetic, bio-targeted molecular recognition en_US
dc.type Preprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Unreviewed en_US
dc.description.embargo 2020-12-31

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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada

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