• Theoretical studies of molecule-substrate interaction at complex gold and silicon oxide surfaces using surface and cluster models 

  Ting, Chao-Ming (2021-01-11)

  The formation and patterns of a monolayer are determined by the interplay of two fundamental interactions, adsorbate-substrate and intermolecular interactions. The binding strength between adsorbate and substrate affects ...
• Direct, quantitative analysis of organic contaminants in complex samples using membrane introduction mass spectrometry with electron and chemical ionization 

  Vandergrift, Gregory William (2021-01-07)

  Condensed phase membrane introduction mass spectrometry (CP-MIMS) is a direct, in situ analysis technique that is well suited to persistent organic pollutants, pesticides, and other small molecules. In CP-MIMS, neutral ...
• Design, synthesis and evaluation of calix[4]arene based enrichment agents for N-methyl proteomics 

  Shaurya, Alok (2021-01-06)

  Role of N-methylated lysines (K) and arginines (R) was underappreciated for a long time before the turn of the century. With the help of new emerging technologies, their crucial role in chromatin regulation was established ...
• Synthesis, characterization and application of crosslinked functionalized polydicyclopentadiene 

  Li, Tong (2021-01-06)

  Dicyclopentadiene (DCPD), a tricyclic olefin, is available from the C5 fraction of petroleum feedstocks. Owing to its high reactivity (due to the presence of a strained alkene), low cost, and lack of other commercial uses, ...
• Real-time mass spectrometric monitoring of chemical processes 

  Omari, Isaac Obeng (2021-01-05)

  Reactions can be monitored in real-time or off-line for qualitative and quantitative information on reaction systems under study. The work presented in this dissertation was focused on the application of reaction monitoring ...
• Anaerobic electrospray ionization mass spectrometry of methylalumoxane and zirconium complexes 

  Joshi, Anuj (2020-12-22)

  In this thesis, the reactivity and synthesis of methylalumoxane (MAO) via electrospray ionization mass spectrometry (ESI-MS) was investigated. The olefin polymerization catalyst [Cp2Zr(μ-Me)2AlMe2]+ [B(C6F5)4]− was also ...
• Quantifying the adhesion strength of microalgae on polydimethylsiloxane surfaces 

  Wan, Zhijing (2020-12-21)

  Silicone rubber is a promising candidate for the next generation of electrical insulators on account of the prolonged hydrophobicity of the polymers. However, microalgae biofouling is always a concern for high voltage ...
• Design, synthesis and reactivity of novel carbazole-bis(azole) ligands for use in lanthanide and transition metal complexes 

  Gajecki, Leah (2020-12-21)

  An array of carbazole-bis(azole) (CzTR and CzTrR, Cz = carbazole, T = tetrazole, Tr = triazole, R = Me, iPr, Bz and CH2Mes) pincer ligands were synthesized and fully characterized by NMR, X-ray crystallography and high ...
• Detection of electrooxidation products using microfluidic devices and Raman spectroscopy 

  Li, Tianyu (2020-09-03)

  Microfluidic flow devices coupled with quantitative Raman spectroscopy are able to provide a deep insight into the reaction mechanism and kinetics of electrocatalytic reactions. With a microfluidic flow device made with ...
• Kinetics of the initial stages of platinum oxidation 

  Stubb, Natalie (2020-08-31)

  The kinetics of the oxidation of platinum metal have long been a topic of interest in the field of electrochemistry. Using a combination of cyclic voltammetry, potential step experiments, and sweep-hold experiments, this ...
• Development and application of structural prediction methods for flexible protein–ligand interactions 

  McFarlane, James M.B. (2020-08-31)

  This dissertation presents a collection of biological simulations and predictions in collaboration with experiment to support and elucidate the trends observed in various protein–ligand systems. Within the model systems, ...
• Controlled microfluidic synthesis of biological stimuli-responsive polymer nanoparticles for drug delivery applications 

  Huang, Yuhang (2020-08-28)

  Polymer nanoparticles (PNPs) that exhibit selective stimuli-responsive degradation and drug release at tumor sites are promising candidates in the development of smart nanomedicines. In this thesis, we demonstrate a ...
• Interconversion of nickel hydroxides studied using dynamic electrochemical impedance 

  Aiyejuro, Victor Omoatokwe (2020-08-27)

  The interconversion of α- and β-Ni(OH)₂ was studied using cyclic voltammetry and dynamic electrochemical impedance (dEIS). Holding experiments were done at 0.5 V, 0.6 V, 0.8 V and 1.0 V while subsequent cathodic holds were ...
• Modification of aspect ratio and surface charge to decrease sequestration of MRI contrast nanomaterials 

  Van Gordon, Kyle (2020-06-30)

  Contrast agents for magnetic resonance imaging (MRI) are but one of a variety of nanosystems that have incredible potential for the detection and diagnosis of cancer. Nanosystems share a common disadvantage: they are quickly ...
• A systems chemistry approach to understanding cucurbit[7]uril-guest dynamics 

  Vos, Kevin Andrew (2020-06-05)

  Systems chemistry is an emerging field of chemistry that studies complex mixtures of molecules that give rise to emergent properties that are not always predictable when studying the components of the mixtures in isolation. ...
• Functionalization of bicyclo[3.2.1] sulfones 

  Un, Chak Hong Andy (2020-05-18)

  Sulfones are useful bioisosteres in drug discovery, and have an unusual ability to engage in binding with both polar and nonpolar regions of target proteins. Despite this, they have seen limited use in drug-screening ...
• Antibody-free affinity enrichment for global methyllysine discovery 

  Dewar, Charlotte (2019-12-20)

  Lysine methylation is a post-translational modification that regulates a large array of functionally diverse processes that are vital for cellular function. The role of methylation is best characterized on histone proteins ...
• Theoretical investigations of molecular self-assembly on symmetric surfaces 

  Tuca, Emilian (2019-10-28)

  Surface self-assembly, the spontaneous aggregation of molecules into ordered, sta- ble, noncovalently joined structures in the presence of a surface, is of great importance to the bottom-up manufacturing of materials ...
• Assemblies and supramolecular sensors that operate in competitive aqueous solutions and biofluids 

  Beatty, Meagan (2019-09-27)

  Nature has inspired chemists to develop complex assemblies that perform functions in biologically relevant solutions. Yet this is not a trivial task. Not only does water act as a competitive medium but the salts that are ...
• Monitoring early stages of bacterial adhesion at silica surfaces through image analysis 

  Sun, Victor (2019-09-03)

  Understanding bacterial adhesion and biofilm formations on abiotic surfaces are important biological processes that affect the growth of bacteria, with its far-spreading impacts on in everyday life, either as a benefactor ...

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