• A Photophysical Investigation on the Role of Complexity on Controlling the Functions of Pluronic F127 and Sodium Deoxycholate Supramolecular Hydrogels 

  Awasthi, Ankur (2023-09-29)

  Colloidal states of matter, where a solid three-dimensional network entraps a liquid mobile phase are known as gels. Based on the nature of the interactions between the building blocks that constitute the solid matrix, ...
• Paper Spray Mass Spectrometry for the Quantitation of Drugs of Abuse in Biofluids and Street Drug Samples 

  Borden, Scott A. (2023-09-29)

  Paper spray mass spectrometry (PS-MS) has been developed as a tool for the analysis of drugs of abuse (DoA) in street drug samples, urine, and oral fluid. PS-MS is presented as a viable alternative to the traditional gas ...
• Using the surfaces of droplets formed using droplet-based microfluidic technologies to study biomolecular interactions 

  McDonald, Alex R. (2023-09-01)

  This thesis explores droplet-based microfluidic technologies to fabricate bespoke emulsions, focusing on lipid- and protein-based interactions on the surface of the droplets. I introduce microfluidic technologies for droplet ...
• Investigating the Influence of Chirality and Stable Free Radicals on the Optical and Electrical Properties of Charge Transfer Dyes 

  Templeman-Vivian, Bennett (2023-08-31)

  As the demand for advanced electronics continues, there is an increasing need for the development of technology and infrastructure to support these advancements. This thesis aims to address this need by exploring the ...
• Microfluidic Synthesis of Silver Loaded, pH Sensitive, Nanogels for Enhanced Radiotherapy 

  Boulding, Kyra (2023-08-31)

  Radiation therapy (RT) is an effective and commonly used course of treatment for cancer. However, RT lacks specificity resulting in sever acute and chronic side effects. Radiosensitizers, like silver nanoparticles (Ag NPs), ...
• Application of Raman Spectroscopy for the characterization of carbon materials 

  Guilherme da Fonseca, Bruno (2023-08-30)

  This dissertation discusses the applications of Raman spectroscopy for the characterization of carbon materials, through the investigation of heterogeneous hydrogenation, estimation of elemental and organic carbon from ...
• Exploring Charge-Transfer Properties of Donor-Acceptor Functionalized Squaraine Dyes 

  Stanley, Austin (2023-08-28)

  In the realm of optoelectronics and solar technology, the demand for efficient and cost-effective materials has intensified. Squaraine dyes have emerged as a promising class of compounds for these applications, owing to ...
• Advances with Solid Substrate Spray Mass Spectrometry for Quantitative Illicit Drug Measurement 

  Laxton, John-Clare (2023-08-28)

  The opioid crisis continues to be the leading cause of overdose and death among people who use drugs (PWUD). Harm reduction drug checking (HRDC) services aimed at preventing accidental overdose events do so by offering ...
• Modelling mechanisms of organometallic reactions from surface deposition to heterogeneous catalysis 

  Donnecke, Sofia (2023-08-25)

  Theoretical and experimental methods are applied to study the elementary steps taking place in the gas phase and on the surface to help guide the rational design of new precursors and catalysts. The body of this work ...
• Efficient upcycling of low-functionality polymers using trifluoromethyl aryl diazirine chemistry 

  Bi, Liting (2023-08-14)

  Crosslinking technologies are widely employed in our daily life: from silicone bakeware to epoxy adhesives and rubber tires. Traditionally, however, each type of commodity polymer substrate requires the use of a specific ...
• Fundamental studies and potential optoelectronic applications of living crystallization-driven self-assembly 

  Lei, Shixing (2023-08-14)

  Self-assembled nanostructures are receiving intense current attention because of their fascinating multifunctional properties and potential uses in the emerging field of nanoscience. Solution self-assembly of block copolymers ...
• Development of Gold Nanoparticles for Targeting PD-L1-Presenting Breast Cancers 

  Blevins, Derek James (2023-07-31)

  Our goal was to selectively target the immunosuppressive programmed cell death protein ligand 1 (PD-L1) presenting cancer cells with gold nanoparticles (AuNP). Initially, small molecules, described as antagonists for the ...
• Development of Stable, Active, and High-Throughput Experimentation Compatible Palladium Precatalysts 

  Huang, Jingjun (2023-07-27)

  Palladium-catalyzed cross-coupling has an approximately 50-year history, with seminal work in the 1970s leading to widespread use today, resulting in the 2010 Nobel Prize in Chemistry. The robustness of this chemistry, ...
• Development of immunosensors and immunoassays using metallic nanostructures 

  Tuckmantel Bido, Ariadne (2023-06-16)

  Nanoplasmonic biosensors exploit the unique properties that arise from the interaction of light with free electrons of metallic nanostructures. They offer several advantages over the currently most employed methods of ...
• Monitoring Metabolic Alteration in Cancer Cells upon Radiation Therapy by Surface-Enhanced Raman Scattering (SERS) 

  Chen, Xiangyu (2023-05-31)

  Surface-Enhanced Raman Spectroscopy (SERS) is a highly selective and sensitive method that allows the tracking and identification of metabolites at low concentrations in cellular models. In this work, radiation-induced ...
• Flurorescence Study of the Microenvironment of Pyrene Molecules Loaded into Polycaprolactone-block-poly(ethylene oxide) Polymer Nanoparticles and Implications for Drug Delivery 

  Khokhar, Anupjot Singh (2023-04-28)

  Polymer nanoparticles (PNPs) come across as the next generation drug delivery vehicles owing to their advantages such as biocompatibility, improved therapeutic efficacy and reduced toxicity. These biodegradable nanocarriers ...
• Structurally diverse functionalized hosts for the binding of cationic drugs and metabolites 

  Warmerdam, Zoey (2023-04-27)

  The goal for my thesis is to learn about structure-activity relationships between sulfonatocalix[4]arene host and small molecule targets, to extend on the fundamental knowledge that is present in today’s literature. This ...
• Exploring Hydrophosphination Mediated by Molybdenum Phosphenium Complexes 

  Muir, Vanessa (2023-04-27)

  Metal-catalyzed hydrophosphination (HP) has seen huge growth over the last two decades. Almost all catalysts rely on intermediates containing phosphido ligands (PR2⁻). The nucleophilicity of these ligands has resulted in ...
• Development of the Top Layer Method for Measuring the Diffusion Kinetics of Small Molecules in Hydrogels 

  Wang, Guanqiao (2023-04-11)

  Hydrogels have a wide range of applications, such as in everyday personal care products, for the recovery of oil in extraction processes, and as materials for the development of drug delivery vehicles. The design of these ...
• Synthesis and Characterization of Lanthanide-Based Nanocrystals for Novel Quantum Information and Bio-Imaging Applications 

  Frencken, Adriaan (2023-03-21)

  Lanthanide ions show a wide variety of optical and magnetic properties due to their unique 4f-orbital occupations, allowing them use in e.g. telecommunication, ultra-strong magnets, and lasers. Incorporation of these ions ...

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