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The effects of ethanol on bidirectional synaptic plasticity in the hippocampus

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dc.contributor.author Shin, James
dc.date.accessioned 2010-11-16T19:55:34Z
dc.date.available 2010-11-16T19:55:34Z
dc.date.copyright 2009 en
dc.date.issued 2010-11-16T19:55:34Z
dc.identifier.uri http://hdl.handle.net/1828/3117
dc.description.abstract The effects of ethanol on the brain are far reaching. However, the effect of ethanol on synaptic plasticity has not yet been fully explored. Although it has been established that ethanol inhibits long-term potentiation (LTP) in the CA1 of the hippocampus, before our study, it was unclear whether long-term depression (LTD) was attenuated or enhanced by ethanol. We found that different concentrations of ethanol attenuated LTD in the CA1 (CA1-LTD) at younger ages. At more mature ages, CA1-LTD was completely blocked by ethanol. In contrast to this, LTD in the dentate gyrus (DG-LTD) was not significantly affected by ethanol concentrations up to 100 mM at any age group tested. These results suggest there are mechanistic differences in LTD induction in the DG and CA1, using the same induction protocol and that CA1-LTD is ethanol sensitive but DG-LTD is not. en
dc.language English eng
dc.language.iso en en
dc.rights Available to the World Wide Web en
dc.subject Hippocampus en
dc.subject Brain en
dc.subject Ethanol en
dc.subject Alcohol en
dc.subject.lcsh UVic Subject Index::Sciences and Engineering::Biology en
dc.title The effects of ethanol on bidirectional synaptic plasticity in the hippocampus en
dc.type Thesis en
dc.contributor.supervisor Christie, Brian R.
dc.degree.department Dept. of Biology en
dc.degree.level Master of Science M.Sc. en


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