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Browsing Division of Medical Sciences by Title

Browsing Division of Medical Sciences by Title

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  • De la Vega, Laura; Gómez, Diego A. Rosas; Abelseth, Emily; Abelseth, Laila; Allisson da Silva, Victor; Willerth, Stephanie M. (Applied Sciences, 2018-11)
    Most neurological diseases and disorders lack true cures, including spinal cord injury (SCI). Accordingly, current treatments only alleviate the symptoms of these neurological diseases and disorders. Engineered neural ...
  • Rajwani, Azra; Restall, Brendon; Muller, Nathan J.; Roebuck, Scott; Willerth, Stephanie M. (Biosensors, 2017)
    This work developed a prototype of an affordable, long-term water quality detection device that provides a visual readout upon detecting bacterial contamination. This device prototype consists of: (1) enzyme-releasing ...
  • Chen, Lena; Choi, Catherine S.W.; Sanchez-Arias, Juan C.; Arbour, Laura T.; Swayne, Leigh Anne (2019-11-21)
    Ankyrin-B (AnkB) is scaffolding protein that anchors integral membrane proteins to the cardiomyocyte cytoskeleton. We recently identified an AnkB variant, AnkB p.S646F (ANK2 c.1937 C>T) associated with a phenotype ranging ...
  • Boyce, Andrew K.J.; Kim, Michelle S.; Wicki-Stordeur, Leigh E.; Swayne, Leigh Anne (Biochemical Journal, 2015-09)
    The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization ...
  • Vedam, Saraswathi; Stoll, Kathrin; Schummers, Laura; Fairbrother, Nichole; Klein, Michael C; Thordarson, Dana; Kornelsen, Jude; Dharamsi, Shafik; Rogers, Judy; Liston, Robert; Kaczorowski, Janusz (BMC Pregnancy and Childbirth, 2014-10-28)
    Background: Available birth settings have diversified in Canada since the integration of regulated midwifery. Midwives are required to offer eligible women choice of birth place; and 25-30% of midwifery clients plan home ...
  • Wilson, Kenneth S.; Wilson, Amanda G.; Dewar, Gary J. (Canadian Journal of Gastroenterology, 2002)
    OBJECTIVES: To review outcomes after curative treatment for esophageal cancer in the Vancouver Island Cancer Centre from 1993 to 1998. Curative treatments included esophagectomy alone, and chemoradiotherapy with ‘selective ...
  • Arbour, Laura; Melnikov, Vladimir; McIntosh, Sarah; Olsen, Britta; Osborne, Geraldine; Vaktskjold, Arild (International Journal of Circumpolar Health, 2009)
    Objectives. Little is known about the rates of congenital anomalies in the northernmost regions of the world. As in other parts of the world, it is crucial to assess the relative rates and trends of adverse birth outcomes ...
  • Miller, Linda C.; Swayne, Leigh Anne; Chen, Lina; Feng, Zhong-Ping; Wacker, Jennifer L.; Muchowski, Paul J.; Zamponi, Gerald W.; Braun, Janice E. A. (The Journal of Biological Chemistry, 2003)
    Cysteine string protein (CSP), a 34-kDa molecular chaperone, is expressed on synaptic vesicles in neurons and on secretory vesicles in endocrine, neuroendocrine, and exocrine cells. CSP can be found in a complex with two ...
  • Fairbrother, Nichole; Young, Allan H.; Janssen, Patricia; Antony, Martin M.; Tucker, Emma (BMC Psychiatry, 2015-08-25)
    Background: Mood and anxiety and related disorders (AD) account for a significant proportion of mental health conditions, with close to 30 % of the population (28.8 %) suffering from an AD at some time in their life, and ...
  • Napoli, Silvana B.; Vitale, María Paula; Cafiero, Pablo J.; Micheletti, María Belén; Bradichansky, Paula Pedernera; Lejarraga, Celina; Urinovsky, Maria Gabriela; Escalante, Anabella; Rodriguez, Estela; Schiariti, Verónica (International Journal of Environmental Research and Public Health, 2021)
    Background: Autism spectrum disorder (ASD) affects the daily functioning of children and their families; however, in Argentina, there are no standardized tools to guide the description, evaluation, and follow-up of ...
  • Patten, Anna R.; Gil-Mohapel, Joana; Wortman, Ryan C.; Noonan, Athena; Brocardo, Patricia S.; Christie, Brian R. (Brain Sciences, 2013)
    Fetal alcohol spectrum disorders occur when a mother drinks during pregnancy and can greatly influence synaptic plasticity and cognition in the offspring. In this study we determined whether there are periods during brain ...
  • Wicki-Stordeur, Leigh E.; Swayne, Leigh Anne (Frontiers, 2014-01-08)
    Pannexins (Panxs) are a family of single-membrane, large-pore ion, and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically ...
  • Peñasco, Sara; Rico-Barrio, Irantzu; Puente, Nagore; Gómez-Urquijo, Sonia María; Fontaine, Christine J.; Egaña-Huguet, Jon; Achicallende, Svein; Ramos, Almudena; Reguero, Leire; Elezgarai, Izaskun; Nahirney, Patrick C.; Christie, Brian R.; Grandes, Pedro (Neuropharmacology, 2019)
    The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ...
  • Anand, Sonia S.; Abonyi, Sylvia; Arbour, Laura; Balasubramanian, Kumar; Brook, Jeffrey; Castleden, Heather; Chrisjohn, Vicky; Cornelius, Ida; Davis, Albertha Darlene; Desai, Dipika; de Souza, Russell J.; Friedrich, Matthias G.; Harris, Stewart; Irvine, James; L’Hommecourt, Jean; Littlechild, Randy; Mayotte, Lisa; McIntosh, Sarah; Morrison, Julie; Oster, Richard T.; Picard, Manon; Pictou Landing First Nation; Poirier, Paul; Schulze, Karleen M.; Toth, Ellen L. (The Lancet Planet Health, 2019)
    Summary Background Historical, colonial, and racist policies continue to influence the health of Indigenous people, and they continue to have higher rates of chronic diseases and reduced life expectancy compared with ...
  • Yeung, Darwin F; Hsu, Rose (SpringerPlus, 2014-08-05)
    Various paraneoplastic autoimmune phenomena have been reported in patients with myelodysplastic syndromes. We describe a patient who developed expressive aphasia as a paraneoplastic complication of chronic myelomonocytic ...
  • Samson, Jacopo; Piscopo, Irene; Yampolski, Alex; Nahirney, Patrick; Parpas, Andrea; Aggarwal, Amit; Saleh, Raihan; Drain, Charles Michael (Nanomaterials, 2011)
    Plasmid DNA can be used as a template to yield gold, palladium, silver, and chromium nanoparticles of different sizes based on variations in incubation time at 70 °C with gold phosphine complexes, with the acetates of ...
  • Sullivan, Stephen Norman (ISRN Gastroenterology, 2012-04)
    Ten to 25% of healthy persons experience bloating. It is particularly common in persons with the irritable bowel syndrome and constipation. While the cause of bloating remains unknown old explanations such as a excessive ...
  • Genuis, Katrina; Pewarchuk, Jesse (Journal of Medical Case Reports, 2014-09-07)
    Introduction: Granulomatosis with polyangiitis poses a significant diagnostic dilemma due its diverse presentations. Seemly isolated sites of disease, such as oral ulcers, may present to physicians working in primary care ...
  • Bene Watts, Simona (2020-08-23)
    Background: Long QT syndrome (LQTS) is a cardiac condition which predisposes individuals to syncope, seizures, and sudden cardiac death. There is a high prevalence of congenital LQTS in a First Nations community in Northern ...
  • Yau, Sonata Suk Yu; Li, Ang; So, Kwok-Fai (Neural Plasticity, 2015)
    Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms ...

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