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A unified phylogeny-based nomenclature for histone variants

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dc.contributor.author Talbert, Paul B
dc.contributor.author Ahmad, Kami
dc.contributor.author Almouzni, Geneviève
dc.contributor.author Ausió, Juan
dc.contributor.author Berger, Frederic
dc.contributor.author Bhalla, Prem L
dc.contributor.author Bonner, William M
dc.contributor.author Cande, W Zacheus
dc.contributor.author Chadwick, Brian P
dc.contributor.author Chan, Simon W L
dc.contributor.author Cross, George A M
dc.contributor.author Cui, Liwang
dc.contributor.author Dimitrov, Stefan I
dc.contributor.author Doenecke, Detlef
dc.contributor.author Eirin-López, José M
dc.contributor.author Gorovsky, Martin A
dc.contributor.author Hake, Sandra B
dc.contributor.author Hamkalo, Barbara A
dc.contributor.author Holec, Sarah
dc.contributor.author Jacobsen, Steven E
dc.contributor.author Kamieniarz, Kinga
dc.contributor.author Khochbin, Saadi
dc.contributor.author Ladurner, Andreas G
dc.contributor.author Landsman, David
dc.contributor.author Latham, John A
dc.contributor.author Loppin, Benjamin
dc.contributor.author Malik, Harmit S
dc.contributor.author Marzluff, William F
dc.contributor.author Pehrson, John R
dc.contributor.author Postberg, Jan
dc.contributor.author Schneider, Robert
dc.contributor.author Singh, Mohan B
dc.contributor.author Smith, M Mitchell
dc.contributor.author Thompson, Eric
dc.contributor.author Torres-Padilla, Maria-Elena
dc.contributor.author Tremethick, David John
dc.contributor.author Turner, Bryan M
dc.contributor.author Waterborg, Jakob Harm
dc.contributor.author Wollmann, Heike
dc.contributor.author Yelagandula, Ramesh
dc.contributor.author Zhu, Bing
dc.contributor.author Henikoff, Steven
dc.date.accessioned 2014-03-19T17:55:00Z
dc.date.available 2014-03-19T17:55:00Z
dc.date.copyright 2012 en_US
dc.date.issued 2012-05-31
dc.identifier.citation Talbert et al.: A unified phylogeny-based nomenclature for histone variants. Epigenetics & Chromatin 2012 5:7. en_US
dc.identifier.issn http://dx.doi.org/10.1186/1756-8935-5-7
dc.identifier.uri http://www.epigeneticsandchromatin.com/content/5/1/7
dc.identifier.uri http://hdl.handle.net/1828/5200
dc.description BioMed Central en_US
dc.description.abstract Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for them has led to a variety of naming styles, multiple synonyms and misleading homographs that obscure variant relationships and complicate database searches. We propose here a unified nomenclature for variants of all five classes of histones that uses consistent but flexible naming conventions to produce names that are informative and readily searchable. The nomenclature builds on historical usage and incorporates phylogenetic relationships, which are strong predictors of structure and function. A key feature is the consistent use of punctuation to represent phylogenetic divergence, making explicit the relationships among variant subtypes that have previously been implicit or unclear. We recommend that by default new histone variants be named with organism-specific paralog-number suffixes that lack phylogenetic implication, while letter suffixes be reserved for structurally distinct clades of variants. For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure. en_US
dc.description.sponsorship We are grateful for support from EMBO, the Howard Hughes Medical Institute, and the Intramural Research Program of the NIH, National Library of Medicine. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.title A unified phylogeny-based nomenclature for histone variants en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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