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Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation

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dc.contributor.author Wicki-Stordeur, Leigh E.
dc.contributor.author Dzugalo, Adrian D.
dc.contributor.author Swansburg, Rose M.
dc.contributor.author Suits, Jocelyne M.
dc.contributor.author Swayne, Leigh Anne
dc.date.accessioned 2014-07-21T18:27:59Z
dc.date.available 2014-07-21T18:27:59Z
dc.date.copyright 2012 en_US
dc.date.issued 2012-03-29
dc.identifier.citation Wicki-Stordeur et al.: Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation. Neural Development 2012 7:11. en_US
dc.identifier.uri http://www.neuraldevelopment.com/content/7/1/11
dc.identifier.uri http://dx.doi.org/10.1186/1749-8104-7-11
dc.identifier.uri http://hdl.handle.net/1828/5477
dc.description BioMed Central en_US
dc.description.abstract Background: Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in neuronal development. Results: We detected pannexin 1 in neural stem and progenitor cells in vitro and in vivo. We manipulated pannexin 1 expression and activity in Neuro2a neuroblastoma cells and primary postnatal neurosphere cultures to demonstrate that pannexin 1 regulates neural stem and progenitor cell proliferation likely through the release of adenosine triphosphate (ATP). Conclusions: Permeable to ATP, a potent autocrine/paracine signaling metabolite, pannexin 1 channels are ideally suited to influence the behavior of neural stem and progenitor cells. Here we demonstrate they play a robust role in the regulation of neural stem and progenitor cell proliferation. Endogenous postnatal neural stem and progenitor cells are crucial for normal brain health, and their numbers decline with age. Furthermore, these special cells are highly responsive to neurological injury and disease, and are gaining attention as putative targets for brain repair. Therefore, understanding the fundamental role of pannexin 1 channels in neural stem and progenitor cells is of critical importance for brain health and disease. en_US
dc.description.sponsorship This work was supported by a Natural Sciences and Engineering Research Council of Canada Discovery Grant, and a University of Victoria laboratory start-up grant awarded to LAS. We thank Jen Graham for assistance with mouse perfusions and decapitations, and we thank Dr. Robert Burke and the UVIC Department of Biochemistry and Microbiology for confocal microscope access. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.subject Postnatal neurogenesis en_US
dc.subject Pannexin 1 en_US
dc.subject Neural stem and progenitor cells en_US
dc.subject Cell proliferation en_US
dc.subject ATP release en_US
dc.title Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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