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Using mathematical modeling to control topographical properties of poly (ε-caprolactone) melt electrospun scaffolds

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dc.contributor.author Ko, J.
dc.contributor.author Bhullar, S.K.
dc.contributor.author Mohtaram, N.K.
dc.contributor.author Willerth, Stephanie
dc.contributor.author Jun, M.B.G.
dc.date.accessioned 2016-05-24T12:12:35Z
dc.date.available 2016-05-24T12:12:35Z
dc.date.copyright 2014 en_US
dc.date.issued 2014-05
dc.identifier.citation Ko, J., Bhullar, S.K., Mohtaram, N.K., Willerth, S.M. & Jun, M.B.G. (2014). Using mathematical modeling to control topographical properties of poly (ε-caprolactone) melt electrospun scaffolds. Journal of Micromechanics and Microengineering, 24(6), 1-13. en_US
dc.identifier.uri http://dx.doi.org/10.1088/0960-1317/24/6/065009
dc.identifier.uri http://hdl.handle.net/1828/7307
dc.description.abstract Melt electrospinning creates fibrous scaffolds using direct deposition. The main challenge of melt electrospinning is controlling the topography of the scaffolds for tissue engineering applications. Mathematical modeling enables a better understanding of the parameters that determine the topography of scaffolds. The objective of this study is to build two types of mathematical models. First, we modeled the melt electrospinning process by incorporating parameters such as nozzle size, counter electrode distance and applied voltage that influence fiber diameter and scaffold porosity. Our second model describes the accumulation of the extruded microfibers on flat and round surfaces using data from the microfiber modeling. These models were validated through the use of experimentally obtained data. Scanning electron microscopy (SEM) was used to image the scaffolds and the fiber diameters were measured using Quartz-PCI Image Management Systems (R) in SEM to measure scaffold porosity. en_US
dc.description.sponsorship Funding support from Natural Sciences and Engineering Research Council (NSERC) Discovery Grants is acknowledged. The authors would also like to acknowledge the Advanced Microscopy Facility at the University of Victoria. en_US
dc.language.iso en en_US
dc.publisher Journal of Micromechanics and Microengineering en_US
dc.subject melt electrospinning en_US
dc.subject modeling en_US
dc.subject topography en_US
dc.subject microfibers en_US
dc.subject scaffolds en_US
dc.title Using mathematical modeling to control topographical properties of poly (ε-caprolactone) melt electrospun scaffolds en_US
dc.type Postprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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