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Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed

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dc.contributor.author Ko, Junghyuk
dc.contributor.author Mohtaram, Nima Khadem
dc.contributor.author Lee, Patrick C.
dc.contributor.author Willerth, Stephanie
dc.contributor.author Jun, Martin B.G.
dc.date.accessioned 2016-05-24T12:27:29Z
dc.date.available 2016-05-24T12:27:29Z
dc.date.copyright 2015 en_US
dc.date.issued 2015
dc.identifier.citation Ko, J., Mohtaram, N.K., Lee, P.C., Willerth, S.M. & Jun, M.B.G. (2015). Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed. Journal of Micromechanics and Microengineering, 25(4), 1-11. en_US
dc.identifier.uri http://dx.doi.org/10.1088/0960-1317/25/4/045018
dc.identifier.uri http://hdl.handle.net/1828/7313
dc.description.abstract Melt electrospinning can be used to fabricate various fibrous biomaterial scaffolds with a range of mechanical properties and varying topographical properties for different applications such as tissue scaffold and filtration and etc., making it a powerful technique. Engineering the topography of such electrospun microfibers can be easily done by tuning the operational parameters of this process. Recent experimental studies have shown promising results for fabricating various topographies, but there is not that body of work that focuses on using mathematical models of this technique to further understand the effect of operational parameters on these properties of microfiber scaffolds. In this study, we developed a novel mathematical model using numerical simulations to demonstrate the effect of temperature, feed rate and flow rate on controlling topographical properties such as fiber diameter of these spun fibrous scaffolds. These promising modelling results are also compared to our previous and current experimental results. Overall, we show that our novel mathematical model can predict the topographical properties affected by key operational parameters such as change in temperature, flow rate and feed rate and this model could serve as a promising strategy for the controlling of topographical properties of such structures for different applications. en_US
dc.description.sponsorship Funding support from Natural Sciences and Engineering Research Council (NSERC) Discovery Grants is acknowledged. The authors would also like to acknowledge the Advanced Microscopy Facility at the University of Victoria. en_US
dc.language.iso en en_US
dc.publisher Journal of Micromechanics and Microengineering en_US
dc.subject Melt electrospinning en_US
dc.subject Modeling en_US
dc.subject Topography en_US
dc.subject Microfibers en_US
dc.subject Scaffolds en_US
dc.title Mathematical model for predicting topographical properties of poly (ε-caprolactone) melt electrospun scaffolds including the effects of temperature and linear transitional speed en_US
dc.type Postprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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