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Label-free plasmonic detection using nanogratings fabricated by laser interference lithography

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dc.contributor.author Hong, Koh Yiin
dc.date.accessioned 2017-03-16T19:45:44Z
dc.date.copyright 2017 en_US
dc.date.issued 2017-01-02
dc.identifier.citation K.Y. Hong, J.W. Menezes, A.G. Brolo, Template Stripping Fabricated Plasmonic Nanogratings for Chemical Sensing, Plasmonics, (2017) 1-7 en_US
dc.identifier.uri http://hdl.handle.net/1828/7849
dc.description.abstract Plasmonics techniques, such as surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS), have been widely used for chemical and biochemical sensing applications. One approach to excite surface plasmons is through the coupling of light into metallic grating nanostructures. Those grating nanostructures can be fabricated using state-of-the-art nanofabrication methods. Laser interference lithography (LIL) is one of those methods that allow the rapid fabrication of nanostructures with a high-throughput. In this thesis, LIL was combined with other microfabrication techniques, such as photolithography and template stripping, to fabricate different types of plasmonic sensors. Firstly, template stripping was applied to transfer LIL-fabricated patterns of one-dimensional nanogratings onto planar supports (e.g., glass slides and plane-cut optical fiber tips). A thin adhesive layer of epoxy resin was used to facilitate the transfer. The UV-Vis spectroscopic response of the nanogratings supported on glass slides demonstrated a strong dependency on the polarization of the incident light. The bulk refractive index sensitivities of the glass-supported nanogratings were dependent on the type of metal (Ag or Au) and the thickness of the metal film. The described methodology provided an efficient low-cost fabrication alternative to produce metallic nanostructures for plasmonic chemical sensing applications. Secondly, we demonstrated a versatile procedure (LIL either alone or combined with traditional laser photolithography) to prepare both large area (i.e. one inch2) and microarrays (μarrays) of metallic gratings structures capable of supporting SPR excitation (and SERS). The fabrication procedure was simple, high-throughput, and reproducible, with less than 5 % array-to-array variations in geometrical properties. The nanostructured gold μarrays were integrated on a chip for SERS detection of ppm-level of 8-quinolinol, an emerging water-borne pharmaceutical contaminant. Lastly, the LIL-fabricated large area nanogratings have been applied for SERS detection of the mixtures of quinolone antibiotics, enrofloxacin, an approved veterinary antibiotic, and one of its active metabolite, ciprofloxacin. The quantification of these analytes (enrofloxacin and ciprofloxacin) in aqueous mixtures were achieved by employing chemometric analysis. The limit of quantification of the method described in this work is in the ppm-level, with <10 % SERS spatial variation. Isotope-edited internal calibration method was attempted to improve the accuracy and reproducibility of the SERS methodology. en_US
dc.language English eng
dc.language.iso en en_US
dc.publisher Plasmonics en_US
dc.rights Available to the World Wide Web en_US
dc.subject Plasmonics en_US
dc.subject Nanogratings en_US
dc.subject Surface enhanced Raman scattering (SERS) en_US
dc.subject Surface plasmon resonance (SPR) en_US
dc.subject Template stripping en_US
dc.subject Microarrays en_US
dc.subject Environmental detection en_US
dc.subject Quinolones en_US
dc.title Label-free plasmonic detection using nanogratings fabricated by laser interference lithography en_US
dc.type Thesis en_US
dc.contributor.supervisor Brolo, Alexandre Guimaraes
dc.degree.department Department of Chemistry en_US
dc.degree.level Doctor of Philosophy Ph.D. en_US
dc.identifier.bibliographicCitation K.Y. Hong, J.W. Menezes, A.G. Brolo, Template Stripping Fabricated Plasmonic Nanogratings for Chemical Sensing, Plasmonics, (2017) 1-7 en_US
dc.description.scholarlevel Graduate en_US
dc.description.embargo 2018-02-17


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