X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea

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dc.contributor.author Keais, Graeme
dc.contributor.author Hanson, Mark
dc.contributor.author Gowen, Brent
dc.contributor.author Perlman, Steve
dc.date.accessioned 2017-07-31T17:24:28Z
dc.date.available 2017-07-31T17:24:28Z
dc.date.copyright 2017 en_US
dc.date.issued 2017-06
dc.identifier.citation Keais, G.L., Hanson, M.A., Gowen, B.E., Perlman, S.J. (2017). X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea. Journal of Evolutionary Biology, 30(6), 1185-1194. doi: 10.1111/jeb.13089 en_US
dc.identifier.uri https://doi.org/10.1111/jeb.13089
dc.identifier.uri http://hdl.handle.net/1828/8385
dc.description.abstract Selfish genes that bias their own transmission during meiosis can spread rapidly in populations, even if they contribute negatively to the fitness of their host. Driving X chromosomes provide a clear example of this type of selfish propagation. These chromosomes have important evolutionary and ecological consequences, and can be found in a broad range of taxa including plants, mammals and insects. Here, we report a new case of X chromosome drive (X drive) in a widespread woodland fly, Drosophila testacea. We show that males carrying the driving X (SR males) sire 80–100% female offspring and possess a diagnostic X chromosome haplotype that is perfectly associated with the sex ratio distortion phenotype. We find that the majority of sons produced by SR males are sterile and appear to lack a Y chromosome, suggesting that meiotic defects involving the Y chromosome may underlie X drive in this species. Abnormalities in sperm cysts of SR males reflect that some spermatids are failing to develop properly, confirming that drive is acting during gametogenesis. By screening wild-caught flies using progeny sex ratios and a diagnostic marker, we demonstrate that the driving X is present in wild populations at a frequency of ~ 10% and that suppressors of drive are segregating in the same population. The testacea species group appears to be a hot spot for X drive, and D. testacea is a promising model to compare driving X chromosomes in closely related species, some of which may even be younger than the chromosomes themselves. en_US
dc.language.iso en en_US
dc.publisher Journal of Evolutionary Biology en_US
dc.subject Drosophila en_US
dc.subject genetic conflict en_US
dc.subject meiotic drive en_US
dc.subject segregation distortion en_US
dc.subject selfish genetic elements en_US
dc.subject X chromosome drive en_US
dc.title X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea en_US
dc.type Preprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US

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