Benchmarking a new three-dimensional ultrasound system for prostate image guided radiation therapy
Date
2008-04-23T19:16:35Z
Authors
Johnston, Holly A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Image guided radiation therapy (IGRT) is a new type of radiotherapy used to deliver lethal doses of radiation to mobile tumors, while preventing surrounding healthy structures from receiving high doses of radiation. It relies on image guidance to track the tumor and ensure its prescribed position in the radiation beam. The main goal
of this work was to determine if a new three-dimensional ultrasound (3D US) image
guidance device, called the Restitu System, could safely replace (or be used interchangeably with) an existing method involving x-ray images of implanted fiducial
markers (FMs) for prostate IGRT. Using comparison statistics called 95 % limits of
agreement (LOA), it was found that the new 3D US system did not produce measurements that agreed sufficiently closely to those made using the FM technique, and therefore, could not safely replace FMs for prostate IGRT. Ultrasound image quality and user variability were determined to have a significant impact on the agreement between the two methods. It was further shown that using the Restitu System offered no significant clinical advantages over a conventional patient re-positioning technique.
Description
Keywords
Radiation Therapy, Prostate Cancer, Ultrasound, Image Guidance