Nanoparticles as MRI contrast agents and biomarkers – applications in prostate cancer and mild traumatic brain injury

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dc.contributor.author Dash, Armita
dc.date.accessioned 2018-01-29T15:41:10Z
dc.date.available 2018-01-29T15:41:10Z
dc.date.copyright 2017 en_US
dc.date.issued 2018-01-29
dc.identifier.uri http://hdl.handle.net/1828/9009
dc.description.abstract Magnetic Resonance Imaging (MRI) is the most prominent non-invasive technique used in clinical diagnosis and biomedical research. Its development as an imaging technique has been aided by contrast agents (CAs) which enhance contrast to noise ratio in the images. This dissertation deals with paramagnetic lanthanide- and superparamagnetic iron-based nanoparticles (NPs) which are potential CAs at clinical field of 3 T and a high field of 9.4 T. Chapter 1 provides a brief overview of colloidal nanoparticles, with an emphasis on their surface chemistry and magnetic properties for bio-applications. Chapter 2 employs europium as an optical probe to illustrate the contribution of inner, second and outer sphere relaxation towards longitudinal and transverse relaxivities of paramagnetic NP-based CAs. Chapter 3 investigates the positive and the negative contrast enhancement abilities and magnetization of paramagnetic NPs comprising a core of sodium dysprosium fluoride with a sodium gadolinium fluoride shell. Their surface chemistry is tuned to target prostate cancer specifically. The application of these NPs is further extended in Chapter 4 to track an intraneuronal protein called tau following mild traumatic brain injury. Chapter 5 deals with facile synthesis and long-term stability of superparamagnetic iron NPs for their potential application as CAs. Chapter 6 illustrates the concept of MRI correlation using ‘T1-only’ and ‘T2-only’ NPs. Chapter 7 investigates on the dynamics involved in the phospholipids coating the surface of NPs. Chapter 8 concludes on the work detailed in the previous chapters and outlines the future outlook. en_US
dc.language.iso en en_US
dc.rights Available to the World Wide Web en_US
dc.subject nanoparticle en_US
dc.subject lanthanide en_US
dc.subject gadolinium en_US
dc.subject dysprosium en_US
dc.subject MRI en_US
dc.subject contrast agent en_US
dc.subject relaxivity en_US
dc.subject prostate cancer en_US
dc.subject traumatic brain injury en_US
dc.subject europium en_US
dc.title Nanoparticles as MRI contrast agents and biomarkers – applications in prostate cancer and mild traumatic brain injury en_US
dc.type Thesis en_US
dc.contributor.supervisor van Veggel, Frank C. J. M.
dc.degree.department Department of Chemistry en_US
dc.degree.level Doctor of Philosophy Ph.D. en_US
dc.description.scholarlevel Graduate en_US
dc.description.embargo 2020-01-15

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