Host–parasite transcriptomics during immunostimulant-enhanced rejection of salmon lice (Lepeophtheirus salmonis) by Atlantic salmon (Salmo salar)

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dc.contributor.author Sutherland, Ben J.G.
dc.contributor.author Covello, Jennifer M.
dc.contributor.author Friend, Sarah E.
dc.contributor.author Poley, Jordan D.
dc.contributor.author Koczka, Kim W.
dc.contributor.author Purcell, Sara L.
dc.contributor.author MacLeod, Tara L.
dc.contributor.author Donovan, Bridget R.
dc.contributor.author Pino, Jorge
dc.contributor.author González-Vecino, Jose Luis
dc.contributor.author Gonzalez, Javier
dc.contributor.author Troncoso, Jose
dc.contributor.author Koop, Ben F.
dc.contributor.author Wadsworth, Simon L.
dc.contributor.author Fast, Mark D.
dc.date.accessioned 2018-08-27T14:35:06Z
dc.date.available 2018-08-27T14:35:06Z
dc.date.copyright 2017 en_US
dc.date.issued 2017
dc.identifier.citation Sutherland, B.J.G.; Covello, J.M.; Friend, S.E.; Poley, J.D.; Koczka, K.W.; Purcell, S.L.; … & Fast, M.D. (2017). Host–parasite transcriptomics during immunostimulantenhanced rejection of salmon lice (Lepeophtheirus salmonis) by Atlantic salmon (Salmo salar). FACETS, 2, 477-495. doi: 10.1139/facets-2017-0020 en_US
dc.identifier.uri https://doi.org/10.1139/facets-2017-0020
dc.identifier.uri https://dspace.library.uvic.ca//handle/1828/9957
dc.description.abstract Salmon lice (Lepeophtheirus salmonis) are important ectoparasites of wild and farmed salmonids and cause major losses to the salmon farming industry throughout the Northern Hemisphere. With the emergence of resistance to several commonly used parasiticides, novel control strategies and integration of multiple treatment options are needed, including host immunostimulation. Here, we investigate the effects of a functional feed containing a peptidoglycan and nucleotide formulation on L. salmonis infection of Atlantic salmon (Salmo salar) by characterizing lice infection levels, the expression of several host immune genes, and the parasite transcriptomic response to the immunostimulated host. Although initial infection intensities were low, the low dose (LD) immunostimulant diet reduced the total lice burden by 50% relative to controls. Immunostimulant fed hosts upregulated interleukin-1 beta in the skin and spleen. This gene has been implicated in successful responses of several salmonid species to salmon lice but is typically not observed in Atlantic salmon, suggesting a favorable influence on the immune response. Lice infecting LD immunostimulated salmon overexpressed genes putatively involved in parasite immunity, including carboxylesterases, and underexpressed genes putatively involved in feeding (e.g., proteases). These lice response genes further improve the characterization of the transcriptome of the non-model parasite by identifying genes potentially involved in evading host immunity. en_US
dc.description.sponsorship The authors would like to thank EWOS Innovation, Novartis Animal Health Canada (Dr. Fast's Research Chair in fish health), NSERC Engage and Discovery programs, and Innovation PEI (student and PDF scholarships) for funding this research; Department of Pathology and Microbiology and Merial scholarships at AVC-UPEI for summer research interns; and the Aquatics Facilities and Staff at the Atlantic Veterinary College for their role in maintaining the Atlantic salmon. BJGS was supported during this work by NSERC-CGS and PDF fellowships. en_US
dc.language.iso en en_US
dc.publisher FACETS en_US
dc.subject functional feeds en_US
dc.subject host-parasite interaction en_US
dc.subject immunostimulation en_US
dc.subject salmon aquaculture en_US
dc.subject sea lice en_US
dc.subject transcriptomics en_US
dc.title Host–parasite transcriptomics during immunostimulant-enhanced rejection of salmon lice (Lepeophtheirus salmonis) by Atlantic salmon (Salmo salar) en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US

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