• Autophagy: From structure to metabolism to therapeutic regulation 

  Jardon, Mario A.; Rothe, Katharina; Bortnik, Svetlana; Vezenkov, Lubomir; Jiang, Xiaoyan; Young, Robert N.; Lum, Julian J.; Gorski, Sharon M. (Autophagy, 2013)

  Multidisciplinary approaches are increasingly being used to elucidate the role of autophagy in health and disease and to harness it for therapeutic purposes. The broad range of topics included in the program of the Vancouver ...
• Demographic population cycles and ℛ0 in discretetime epidemic models 

  van den Driessche, P.; Yakubu, Abdul-Aziz (Journal of Biological Dynamics, 2018)

  We use a general autonomous discrete-time infectious disease model to extend the next generation matrix approach for calculating the basic reproduction number, R0, to account for populations with locally asymptotically ...
• Thickly-resolvable block designs 

  Dukes, Peter J.; Ling, Alan C. H.; Malloch, Amanda (The Australasian Journal of Combinatorics, 2016)

  We show that the necessary divisibility conditions for the existence ofaσ-resolvable BIBD(v,k,λ) are sufficient for largev. The key idea isto form an auxiliary graph based on an [r,k]-configuration ...
• Resolvable Group Divisible Designs with Large Groups 

  Dukes, Peter J.; Lamken, Esther R.; Ling, Alan C. H. (The Electronic Journal of Combinatorics, 2016)

  We prove that the necessary divisibility conditions are sufficient for the existence of resolvable group divisible designs with a fixed number of sufficiently large groups. Our method combines an application of the Rees ...
• Incidence structures near configurations of type (n3) ∗ 

  Dukes, Peter J.; Iwasaki, Kaoruko (Ars Mathematica Contemporanea, 2020)

  An (n3) configuration is an incidence structure equivalent to a linear hypergraph on n vertices which is both 3-regular and 3-uniform. We investigate a variant in which one constraint, say 3-regularity, is present, and we ...
• Insight into coral reef ecosystems: investigations into the application of acoustics to monitor coral reefs and how corallivorous fish respond to mass coral mortality. 

  Dimoff, Sean (2021-02-05)

  Coral reefs around the world are threatened by a variety of sources, from localized impacts, including overfishing and coastal development, to global temperature increases and ocean acidification. Conserving these marine ...
• Integrated Solutions for the Water-Energy-Land Nexus: Are Global Models Rising to the Challenge? 

  Johnson, Nils; Burek, Peter; Byers, Edward; Falchetta, Giacomo; Flörke, Martina; Fujimori, Shinichiro; Havlik, Petr; Hejazi, Mohamad; Hunt, Julian; Krey, Volker; Langan, Simon; Nakicenovic, Nebojsa; Palazzo, Amanda; Popp, Alexander; Riahi, Keywan; van Dijk, Michiel; van Vliet, Michelle T. H.; van Vuuren, Detlef P.; Parkinson, Simon; et al. (Water, 2019)

  Increasing human demands for water, energy, food and materials, are expected to accentuate resource supply challenges over the coming decades. Experience suggests that long-term strategies for a single sector could yield ...
• An intrinsic lipid-binding interface controls sphingosine kinase 1 function 

  Pulkoski-Gross, Michael J.; Jenkins, Meredith L.; Truman, Jean-Philip; Salama, Mohamed F.; Clarke, Christopher J.; Burke, John E.; Hannun, Yusuf A.; Obeid, Lina M. (Journal of Lipid Research, 2018)

  Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation. To produce S1P, ...
• Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29 

  Vickers, Chelsea; Liu, Feng; Abe, Kento; Salama-Alber, Orly; Jenkins, Meredith; Springate, Christopher M. K.; Burke, John E.; Withers, Stephen G.; Boraston, Alisdair B. (Journal of Biological Chemistry, 2018)

  Fucoidans are chemically complex and highly heterogeneous sulfated marine fucans from brown macro algae. Possessing a variety of physicochemical and biological activities, fucoidans are used as gelling and thickening agents ...
• Infectivity of SARS-CoV-2 and Other Coronaviruses on Dry Surfaces: Potential for Indirect Transmission 

  Bueckert, Max; Gupta, Rishi; Gupta, Aditi; Garg, Mohit; Mazumder, Asit (Materials, 2020)

  The unwavering spread of COVID-19 has taken the world by storm. Preventive measures like social distancing and mask usage have been taken all around the globe but still, as of September 2020, the number of cases continues ...
• A Discretization Approach for the Nonlinear Fractional Logistic Equation 

  Izadi, Mohammad; Srivastava, H.M. (Entropy, 2020)

  The present study aimed to develop and investigate the local discontinuous Galerkin method for the numerical solution of the fractional logistic differential equation, occurring in many biological and social science ...
• Growth and Physiological Responses of Norway Spruce (Picea abies (L.) H. Karst) Supplemented with Monochromatic Red, Blue and Far-Red Light 

  OuYang, Fangqun; Ou, Yang; Ma, Jianwei; An, Sanping; Zhao, Jun; Wang, Junhui; Kong, Lisheng; Zhang, Hanguo; Tigabu, Mulualem (Forests, 2021)

  Monochromatic red light (R) supplementation is more efficient than blue light (B) in promoting Norway spruce (Picea abies (L.) H. Karst) growth. Transcriptome analysis has revealed that R and B may regulate stem growth by ...
• Taxonomy, distribution and aspects of the biology of some deep-living copepods in B.C. inlets and adjacent water 

  Koeller, Peter Arthur (2021-02-02)

  The bathypelagic copepods Spinocalanus brevicaudatus, Scaphocalanus brevicornis and Heterorhabdus tanneri have established relatively large, permanent breeding populations in Bute and Jervis Inlet, British Columbia. They ...
• Development and Field Validation of Lidocaine-Loaded Castration Bands for Bovine Pain Mitigation 

  Saville, James W.; Ross, Joseph A.; Trefz, Tyler; Schatz, Crystal; Matheson-Bird, Heather; Ralston, Brenda; Granot, Ori; Schmid, Karin; Terry, Richard; Allan, Nicholas D.; Wulff, Jeremy E.; Olson, Merle (Animals, 2020)

  Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding. Despite the various benefits of castration, all methods ...
• Mixing Uncertainties in Low-Metallicity ABC-Stars: The Impact on Stellar Structure and Nucleosynthesis 

  Battino, Umberto; Lederer-Woods, Claudia; Cseh, Borbála; Denissenkov, Pavel; Herwig, Falk (Universe, 2021)

  The slow neutron-capture process (s-process) efficiency in low-mass AGB stars (1.5 < M/M⊙ < 3) critically depends on how mixing processes in stellar interiors are handled, which is still affected by considerable uncertainties. ...
• Molecular analysis of an enigmatic Streptococcus pneumoniae virulence factor: The raffinose-family oligosaccharide utilization system 

  Hobbs, Joanne K.; Meier, Edward P. W.; Pluvinage, Benjamin; Mey, Mackenzie A.; Boraston, Alisdair B. (Journal of Biological Chemistry, 2019)

  Streptococcus pneumoniae is an opportunistic respiratory pathogen that can spread to other body sites, including the ears, brain, and blood. The ability of this bacterium to break down, import, and metabolize a wide range ...
• Dynamic structural biology at the protein membrane interface 

  Burke, John E. (Journal of Biological Chemistry, 2019)

  Since I started doing scientific research, I've been fascinated by the interplay of protein structure and dynamics and how they together mediate protein function. A particular area of interest has been in understanding the ...
• Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2−/− mice 

  Wang, Renxue; Sheps, Jonathan A.; Liu, Lin; Han, Jun; Chen, Patrick S. K.; Lamontagne, Jason; Wilson, Peter D.; Welch, Ian; Borchers, Christoph H.; Ling, Victor (Journal of Lipid Research, 2019)

  Bile acid imbalance causes progressive familial intrahepatic cholestasis type 2 (PFIC2) or type 3 (PFIC3), severe liver diseases associated with genetic defects in the biliary bile acid transporter bile salt export pump ...
• Mass assembly in star formation via interstellar filaments 

  Chen, Michael Chun-Yuan (2021-01-28)

  Understanding how diffuse molecular clouds at large scales (~10 pc) assemble mass into dense, star-forming cores at small scales (~ 0.1 pc) is crucial to building a holistic theory of star formation. While recent observations ...
• Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency 

  Mao, Fengfeng; Liu, Teng; Hou, Xinfeng; Zhao, Hanqing; He, Wenhui; Li, Cong; Jing, Zhiyi; Jianhua, Sui; Wang, Fengchao; Liu, Xiaohui; Han, Jun; Borchers, Christoph H.; Wang, Jian-She; Li, Wenhui (Journal of Biological Chemistry, 2019)

  Sodium taurocholate cotransporting polypeptide (NTCP, encoded by Slc10a1/SLC10A1) deficiency can result in hypercholanemia but no obvious symptoms in both mice and humans. However, the consequence of and response to long-term ...

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