• Development of an integrated microfluidic platform to evaluate radiotherapy response of tumour cells 

  Palacios Sánchez, América (2022-05-02)

  This thesis details the design, fabrication, and testing of two optofluidic platforms, a square fused silica capillary and a MgF2-PDMS microfluidic chip to detect radiation-induced biochemical changes in cells during ...
• Nearshore habitat use, estuarine residency, and conservation priorities for Pacific salmon in the Fraser River, British Columbia 

  Chalifour, Lia (2022-05-02)

  Cumulative effects from multiple anthropogenic stressors over the past three centuries have severely impacted estuarine and coastal habitats, with cascading effects on the species that rely upon them. Pacific salmon ...
• CRISPR/Cas9 mutation of MYB134 and MYB115 to study regulation and functions of proanthocyanidins in poplar roots 

  Liu, Yalin (2022-05-02)

  Secondary metabolites play important roles in tree defense. Proanthocyanidins (PAs), one of the most common secondary metabolites, are widely distributed in trees and woody plants, and are abundant in poplar. In my research, ...
• Well-posedness and blowup results for the swirl-free and axisymmetric primitive equations in a cylinder 

  SadatHosseiniKhajouei, Narges (2022-05-02)

  This thesis is devoted to the motion of the incompressible and inviscid flow which is ax- isymmetric and swirl-free in a cylinder, where the hydrostatic approximation is made in the axial direction. It addresses the ...
• The distribution of trace metals and their relationship to net community production during two marine heatwave events in the subarctic northeast Pacific Ocean 

  Taves, Robyn (2022-04-29)

  The marine biological carbon pump (BCP) leads to the transfer of carbon from the atmosphere to the ocean interior through the growth of photosynthetic plankton in the euphotic zone and subsequent sinking of particulate ...
• Advanced wavefront sensing and astrometric techniques for the next generation of extremely large telescopes 

  Taheri, Mojtaba (2022-04-29)

  The new generation of giant ground-based telescopes will see their first light this decade. These state-of-the-art facilities will significantly surpass the resolving power of modern space-based observatories such as the ...
• Holocene fire frequency and links to climate and vegetation history on Pender Island, British Columbia, Canada 

  Giuliano, Camille (2022-04-28)

  Contiguous macroscopic charcoal analyses were performed on a 9.03 m long lake sediment core from Roe Lake on Pender Island in the Gulf Islands National Park Reserve of British Columbia, Canada to reconstruct the island’s ...
• Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity 

  Mesa Perez, Monica (2022-04-27)

  The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism ...
• The dynamics of Pythagorean Triples 

  Acar, Nazim (2022-04-27)

  A Pythagorean Triple($PT$) is a triple of positive integers $(a,b,c)$, that satisfies\\ $a^2+b^2=c^2$. By requiring two of the entries being relatively prime, $(a,b,c)$ becomes a Primitive Pythagorean Triple($PPT$). This ...
• Immune regulatory metabolites in the tumor microenvironment suppress T cell function in ovarian cancer 

  Kilgour, Marisa (2022-04-26)

  Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients ...
• Precision nanofibers for biomedical applications via living crystallization-driven self-assembly 

  Garcia Hernandez, Juan Diego (2022-04-25)

  Nature provides fascinating examples of functional materials with hierarchical structures. Nano and microscale materials have been prepared by synthetic approaches via the self-assembly of discrete building blocks with the ...
• Scalable 1D and 2D polymer-based nanoparticles via crystallization-driven self-assembly 

  Ellis, Charlotte Emily (2022-04-21)

  Self-assembly is ubiquitous in nature. A diverse range of materials with exceptional properties are accessed from a limited number of sub-units, through controlling structural order on all length-scales. Achieving the same ...
• Advancing understanding of secondary cell wall polymer binding and synthesis in S-layers of Gram-Positive bacteria 

  Legg, Max (2022-04-21)

  Self-assembling protein surface layers (S-layers) are ubiquitous prokaryotic cell-surface structures involved in structural maintenance, nutrient diffusion, host adhesion, virulence, and many additional processes, which ...
• Glacial isostatic adjustment modelling of the Coast Mountains of British Columbia 

  Lauch, Maximilian (2022-04-20)

  The Coast Mountains in British Columbia contain over 10,000 km2 of glacial ice. While these glaciers have lost significant mass since the Little Ice Age (LIA; around 300 years before present), the melting rate has significantly ...
• Simulating the universe: the evolution of the most massive galaxies 

  Rennehan, Douglas (2022-04-19)

  The cores of galaxy clusters contain the most massive galaxies in the Universe, the brightest cluster galaxies. These galaxies are unique compared to their counterpart galaxies outside of clusters as they have much ...
• Automatic classification of fish and bubbles at pixel-level precision in multi-frequency acoustic echograms using U-Net convolutional neural networks 

  Slonimer, Alex (2022-04-05)

  Multi-frequency backscatter acoustic profilers (echosounders) are used to measure biological and physical phenomena in the ocean in ways that are not possible with optical methods. Echosounders are commonly used on ocean ...
• Effect of cucurbit[6]uril on the structure and dynamics of NaDC gels 

  Talluri, Sree Gayathri (2022-04-04)

  Gels are colloidal states of matter in which a solid matrix is dispersed in a liquid phase. Supramolecular gels are formed due to the self-assembly of small gelator molecules in a suitable solvent as a result of specific ...
• Structure of prion β-oligomers as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations 

  Serpa, Jason J.; Popov, Konstantin I.; Petrotchenk, Evgeniy V.; Dokholyan, Nikolay V.; Borchers, Christoph H. (Journal of Proteomics, 2021-11)

  The conversion of the native monomeric cellular prion protein (PrPC) into an aggregated pathological β-oligomeric form (PrPβ) and an infectious form (PrPSc) is the central element in the development of prion diseases. The ...
• Chinook and Coho salmon hybrids linked to habitat and climatic changes on Vancouver Island, British Columbia 

  Araujo, H. Andres; Duguid, William D.P.; Withler, Ruth; Supernault, Janine; Schulze, Angela D.; Mckenzie, Jessica L.; Pellett, Kevin; Beacham, Terry D.; Jonsen, Kim; Gummer, Anna (Ecology and Evolution, 2021-11)

  Between 2013 and 2019, 63 presumed Chinook salmon Oncorhynchus tshawytscha sampled primarily in the Strait of Georgia (0.63% of total sample) were identified as potential Chinook–Coho (Oncorhynchus kisutch) hybrids by the ...
• Binding Methylarginines and Methyllysines as Free Amino Acids: A Comparative Study of Multiple Host Classes 

  Warmerdam, Zoey; Kamba, Bianca E.; Le, My-Hue; Schrader, Thomas; Isaacs, Lyle; Bayer, Peter; Hof, Fraser (ChemBioChem, 2021-11)

  Methylated free amino acids are an important class of targets for host-guest chemistry that have recognition properties distinct from those of methylated peptides and proteins. We present comparative binding studies for ...

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