WT1 has two main isoforms: WT1(-KTS) and WT1(+KTS). Both are known to bind to a DNA consensus sequence with different affinities, and are thus postulated to play overlapping but distinct functional roles in the cell. WT1 ...

The surface molecules (procyclins) of procyclic forms of African trypanosomes (Trypanosoma brucei spp.) are complex mixtures of lipid-anchored glycoconjugates. The procyclins are expressed differentially during the parasite ...

Aniridia is a rare genetic disorder that affects the development of the eye and is caused in most cases by mutations in the PAX6 gene. Patients with a heterozygous mutation in their PAX6 gene are born without irises. ...

Aeromonas calmonicida is a Gram negative rod shaped bacterium capable of causing furunculosis in salmonid fish and other chronic and inflammatory diseases in goldfish, carp and also salmonids. The surface layer of A. ...

Protein-carbohydrate interactions are pivotal to many biological processes, from plant cell wall degradation to host-pathogen interactions. Many of these processes require the deployment of carbohydrate-active enzymes in ...

Shope fibroma virus (SFV) N1R is a member of a family of poxvirus proteins that is associated with virulence and largely defined by the presence of a C-terminal RING finger motif and localization to virus factories within ...

The work presented herein is a method optimization for biomolecule detection and identification using Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI). MALDI-MSI is a unique form of mass ...

Despite ongoing advancement in detection and treatment, breast cancer remains a major clinical challenge worldwide. Cancer has traditionally been conceptualized as a ‘disease of the genes’ by virtue of the mutagenic events ...

The release of 260 kg of polychlorinated biphenyls (PCBs) by a military radar station into Saglek Bay (Labrador) in the eastern Canadian Arctic contaminated adjacent marine sediments, and some fish, seabirds, and ringed ...

In 1871, a unique substance was isolated from the white blood cells of pus. This substance, which later became known as chromatin, was shown to be a nucleoprotein complex which encompasses the majority of genomic DNA in ...