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Browsing by Subject "p38 mitogen-activated protein kinase"

Browsing by Subject "p38 mitogen-activated protein kinase"

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  • Phase 1 and pharmacokinetic study of LY3007113, a p38 MAPK inhibitor, in patients with advanced cancer 
    Goldman, J.W.; Rosen, L.S.; Tolcher, A.W.; Papdopolous, K.; Beeram, M.; Shi, P.; Pitou, C.; Bell, R.; Kulanthaivel, P.; Zhang, Xuekui; Fink, A.; Chan, E.M.; Shahir, A.; Farrington, D.; Patnaik, A. (Invest New Drugs, 2018)
    Background The signaling protein p38 mitogenactivated protein kinase (MAPK) regulates the tumor cell microenvironment, modulating cell survival, migration, and invasion. This phase 1 study evaluated the safety of p38 ...