Microfluidic-Based Multi-Organ Platforms for Drug Discovery

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dc.contributor.author Kolahchi, Ahmad Rezaei
dc.contributor.author Mohtaram, Nima Khadem
dc.contributor.author Modarres, Hassan Pezeshgi
dc.contributor.author Mohammadi, Mohammad Hossein
dc.contributor.author Geraili, Armin
dc.contributor.author Jafari, Parya
dc.contributor.author Akbari, Mohsen
dc.contributor.author Sanati-Nezhad, Amir
dc.date.accessioned 2019-01-07T20:05:56Z
dc.date.available 2019-01-07T20:05:56Z
dc.date.copyright 2016 en_US
dc.date.issued 2016
dc.identifier.citation Kolahchi, A.R., Mohtaram, N.K., Modarres, H.P., Mohammadi, M.H., Geraili, A., Jafari, P., Akbari, M. & Sanati-Nezhad, A. (2016). Microfluidic-Based Multi-Organ Platforms for Drug Discovery. Micromachines, 7(9), 162. https://doi.org/10.3390/mi7090162 en_US
dc.identifier.uri https://doi.org/10.3390/mi7090162
dc.identifier.uri https://dspace.library.uvic.ca//handle/1828/10489
dc.description.abstract Development of predictive multi-organ models before implementing costly clinical trials is central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality. Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro- and nanotechnology, and in silico modeling have enabled single- and multi-organ platforms for investigation of new chemical agents and tissue-tissue interactions. This review provides an overview of the principles of designing microfluidic-based organ-on-chip models for drug testing and highlights current state-of-the-art in developing predictive multi-organ models for studying the cross-talk of interconnected organs. We further discuss the challenges associated with establishing a predictive body-on-chip (BOC) model such as the scaling, cell types, the common medium, and principles of the study design for characterizing the interaction of drugs with multiple targets. en_US
dc.description.sponsorship This work was supported by the Natural Sciences and Engineering Research Council of Canada, and Alberta Innovates-Bio Solutions. en_US
dc.language.iso en en_US
dc.publisher Micromachines en_US
dc.subject drug discovery en_US
dc.subject body-on-chip en_US
dc.subject microfluidics en_US
dc.subject organ-on-chip en_US
dc.subject in silico modeling en_US
dc.title Microfluidic-Based Multi-Organ Platforms for Drug Discovery en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US

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