Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus

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dc.contributor.author Peñasco, Sara
dc.contributor.author Rico-Barrio, Irantzu
dc.contributor.author Puente, Nagore
dc.contributor.author Gómez-Urquijo, Sonia María
dc.contributor.author Fontaine, Christine J.
dc.contributor.author Egaña-Huguet, Jon
dc.contributor.author Achicallende, Svein
dc.contributor.author Ramos, Almudena
dc.contributor.author Reguero, Leire
dc.contributor.author Elezgarai, Izaskun
dc.contributor.author Nahirney, Patrick C.
dc.contributor.author Christie, Brian R.
dc.contributor.author Grandes, Pedro
dc.date.accessioned 2019-06-17T16:25:13Z
dc.date.available 2019-06-17T16:25:13Z
dc.date.copyright 2019 en_US
dc.date.issued 2019
dc.identifier.citation Peñasco , S., Rico-Barrio, I., Puente, N., Gómez-Urquijo, S.M., Fontaine, C.J., Egaña-Huguet, J., … Grandes, P. (2019). Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus. Neuropharmacology, 153, 32-40. https://doi.org/10.1016/j.neuropharm.2019.04.020 en_US
dc.identifier.uri https://doi.org/10.1016/j.neuropharm.2019.04.020
dc.identifier.uri http://hdl.handle.net/1828/10924
dc.description.abstract The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. Here, immuno-electron microscopy in adult mice showed that ∼26% of the excitatory synaptic terminals in the middle 1/3 of the dentate molecular layer (DML) contained CB1 receptors, and field excitatory postsynaptic potentials evoked by MPP stimulation were inhibited by CB1 receptor activation. In addition, MPP stimulation at 10 Hz for 10 min triggered CB1 receptor-dependent excitatory long-term depression (eCB-eLTD) at MPP synapses of wild-type mice but not on CB1-knockout mice. This eCB-eLTD was group I mGluR-dependent, required intracellular calcium influx and 2-arachydonoyl-glycerol (2-AG) synthesis but did not depend on N-methyl-d-aspartate (NMDA) receptors. Overall, these results point to a functional role for CB1 receptors with eCB-eLTD at DML MPP synapses and further involve these receptors in memory processing within the adult brain. en_US
dc.description.sponsorship This work was supported by MINECO/FEDER, UE (grant number SAF2015-65034-R to PG); The Basque Government (grant number BCG IT764-13 to PG); Red de Trastornos Adictivos, Instituto de Salud Carlos III (ISC-III) and European Regional Development Funds-European Union (ERDF-EU; grant RD16/0017/0012 to PG); PhD contract from MINECO (BES-2013-065057 to SP); Vanier Canada Graduate Scholarship (NSERC to CJF). en_US
dc.language.iso en en_US
dc.publisher Neuropharmacology en_US
dc.subject CB1 receptor en_US
dc.subject 2-AG en_US
dc.subject Electrophysiology en_US
dc.subject Excitatory synapses en_US
dc.subject Long-term depression en_US
dc.subject Hippocampus en_US
dc.title Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US

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