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Browsing Faculty Publications (Medical Sciences) by Title

Browsing Faculty Publications (Medical Sciences) by Title

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  • De la Vega, Laura; Gómez, Diego A. Rosas; Abelseth, Emily; Abelseth, Laila; Allisson da Silva, Victor; Willerth, Stephanie M. (Applied Sciences, 2018-11)
    Most neurological diseases and disorders lack true cures, including spinal cord injury (SCI). Accordingly, current treatments only alleviate the symptoms of these neurological diseases and disorders. Engineered neural ...
  • Lee, Thomas H.; Christie, Brian R.; van Praag, Henriette; Lin, Kangguang; Siu, Parco Ming-Fai; Xu, Aimin; So, Kwok-Fai; Yau, Suk-yu (International Journal of Molecular Sciences, 2021)
    AdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti-atherogenic, and anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross the blood-brain barrier, its chronic ...
  • Chen, Michael X.; Su, Ho-Hsuan; Shiao, Ching-Ya; Chang, Yu-Ting; Chang, Ming-Chu; Kao, Chih-Chin; Wang, San-Yuan; Shih, His-Chang; Tsai, I-Lin (International Journal of Molecular Sciences, 2021)
    Type 1 autoimmune pancreatitis (AIP) is categorized as an IgG4-related disease (IgG4-RD), where a high concentration of plasma IgG4 is one of the common biomarkers among patients. IgG Fc-glycosylation has been reported ...
  • Rajwani, Azra; Restall, Brendon; Muller, Nathan J.; Roebuck, Scott; Willerth, Stephanie M. (Biosensors, 2017)
    This work developed a prototype of an affordable, long-term water quality detection device that provides a visual readout upon detecting bacterial contamination. This device prototype consists of: (1) enzyme-releasing ...
  • Chen, Lena; Choi, Catherine S.W.; Sanchez-Arias, Juan C.; Arbour, Laura T.; Swayne, Leigh Anne (2019-11-21)
    Ankyrin-B (AnkB) is scaffolding protein that anchors integral membrane proteins to the cardiomyocyte cytoskeleton. We recently identified an AnkB variant, AnkB p.S646F (ANK2 c.1937 C>T) associated with a phenotype ranging ...
  • Boyce, Andrew K.J.; Kim, Michelle S.; Wicki-Stordeur, Leigh E.; Swayne, Leigh Anne (Biochemical Journal, 2015-09)
    The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In the present study, we provide striking evidence that ATP, in turn, stimulates internalization ...
  • Vedam, Saraswathi; Stoll, Kathrin; Schummers, Laura; Fairbrother, Nichole; Klein, Michael C; Thordarson, Dana; Kornelsen, Jude; Dharamsi, Shafik; Rogers, Judy; Liston, Robert; Kaczorowski, Janusz (BMC Pregnancy and Childbirth, 2014-10-28)
    Background: Available birth settings have diversified in Canada since the integration of regulated midwifery. Midwives are required to offer eligible women choice of birth place; and 25-30% of midwifery clients plan home ...
  • Henri-Bhargava, Alexandre; Herrmann, Nathan; Ismail, Zahinoor; Collins, Rhonda; Desmarais, Philippe; Goodarzi, Zahra; Iaboni, Andrea; Kirkham, Julia; Massoud, Fadi; Moser, Andrea; Silvius, James; Watt, Jennifer; Seitz, Dallas (Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022-01-31)
    Introduction Cognitive enhancers (ie, cholinesterase inhibitors and memantine) can provide symptomatic benefit for some individuals with dementia; however, there are circumstances in which the risks of continuing treatment ...
  • Wilson, Kenneth S.; Wilson, Amanda G.; Dewar, Gary J. (Canadian Journal of Gastroenterology, 2002)
    OBJECTIVES: To review outcomes after curative treatment for esophageal cancer in the Vancouver Island Cancer Centre from 1993 to 1998. Curative treatments included esophagectomy alone, and chemoradiotherapy with ‘selective ...
  • Arbour, Laura; Melnikov, Vladimir; McIntosh, Sarah; Olsen, Britta; Osborne, Geraldine; Vaktskjold, Arild (International Journal of Circumpolar Health, 2009)
    Objectives. Little is known about the rates of congenital anomalies in the northernmost regions of the world. As in other parts of the world, it is crucial to assess the relative rates and trends of adverse birth outcomes ...
  • Miller, Linda C.; Swayne, Leigh Anne; Chen, Lina; Feng, Zhong-Ping; Wacker, Jennifer L.; Muchowski, Paul J.; Zamponi, Gerald W.; Braun, Janice E. A. (The Journal of Biological Chemistry, 2003)
    Cysteine string protein (CSP), a 34-kDa molecular chaperone, is expressed on synaptic vesicles in neurons and on secretory vesicles in endocrine, neuroendocrine, and exocrine cells. CSP can be found in a complex with two ...
  • Fairbrother, Nichole; Young, Allan H.; Janssen, Patricia; Antony, Martin M.; Tucker, Emma (BMC Psychiatry, 2015-08-25)
    Background: Mood and anxiety and related disorders (AD) account for a significant proportion of mental health conditions, with close to 30 % of the population (28.8 %) suffering from an AD at some time in their life, and ...
  • Napoli, Silvana B.; Vitale, María Paula; Cafiero, Pablo J.; Micheletti, María Belén; Bradichansky, Paula Pedernera; Lejarraga, Celina; Urinovsky, Maria Gabriela; Escalante, Anabella; Rodriguez, Estela; Schiariti, Verónica (International Journal of Environmental Research and Public Health, 2021)
    Background: Autism spectrum disorder (ASD) affects the daily functioning of children and their families; however, in Argentina, there are no standardized tools to guide the description, evaluation, and follow-up of ...
  • Patten, Anna R.; Gil-Mohapel, Joana; Wortman, Ryan C.; Noonan, Athena; Brocardo, Patricia S.; Christie, Brian R. (Brain Sciences, 2013)
    Fetal alcohol spectrum disorders occur when a mother drinks during pregnancy and can greatly influence synaptic plasticity and cognition in the offspring. In this study we determined whether there are periods during brain ...
  • Wicki-Stordeur, Leigh E.; Swayne, Leigh Anne (Frontiers, 2014-01-08)
    Pannexins (Panxs) are a family of single-membrane, large-pore ion, and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically ...
  • Peñasco, Sara; Rico-Barrio, Irantzu; Puente, Nagore; Gómez-Urquijo, Sonia María; Fontaine, Christine J.; Egaña-Huguet, Jon; Achicallende, Svein; Ramos, Almudena; Reguero, Leire; Elezgarai, Izaskun; Nahirney, Patrick C.; Christie, Brian R.; Grandes, Pedro (Neuropharmacology, 2019)
    The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ...
  • Rico-Barrio, Irantzu; Peñasco, Sara; Lekunberri, Leire; Serrano, Maitane; Egaña-Huguet, Jon; Mimenza, Amaia; Soria-Gomez, Edgar; Ramos, Almudena; Buceta, Ianire; Gerrikagoitia, Immaculada; Mendizabal-Zubiaga, Juan; Elezgarai, Izaskun; Puente, Nagore; Grandes, Pedro (Biomedicines, 2021)
    Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers ...
  • Anand, Sonia S.; Abonyi, Sylvia; Arbour, Laura; Balasubramanian, Kumar; Brook, Jeffrey; Castleden, Heather; Chrisjohn, Vicky; Cornelius, Ida; Davis, Albertha Darlene; Desai, Dipika; de Souza, Russell J.; Friedrich, Matthias G.; Harris, Stewart; Irvine, James; L’Hommecourt, Jean; Littlechild, Randy; Mayotte, Lisa; McIntosh, Sarah; Morrison, Julie; Oster, Richard T.; Picard, Manon; Pictou Landing First Nation; Poirier, Paul; Schulze, Karleen M.; Toth, Ellen L. (The Lancet Planet Health, 2019)
    Summary Background Historical, colonial, and racist policies continue to influence the health of Indigenous people, and they continue to have higher rates of chronic diseases and reduced life expectancy compared with ...
  • Yeung, Darwin F; Hsu, Rose (SpringerPlus, 2014-08-05)
    Various paraneoplastic autoimmune phenomena have been reported in patients with myelodysplastic syndromes. We describe a patient who developed expressive aphasia as a paraneoplastic complication of chronic myelomonocytic ...
  • Samson, Jacopo; Piscopo, Irene; Yampolski, Alex; Nahirney, Patrick; Parpas, Andrea; Aggarwal, Amit; Saleh, Raihan; Drain, Charles Michael (Nanomaterials, 2011)
    Plasmid DNA can be used as a template to yield gold, palladium, silver, and chromium nanoparticles of different sizes based on variations in incubation time at 70 °C with gold phosphine complexes, with the acetates of ...

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