Approaches to Detection of Distantly Related Proteins by Database Searches
Date
1996-12
Authors
Cattell, K.
Koop, B.
Olafson, R.S.
Fellows, M.
Bailey, I.
Olafson, R.W.
Upton, C.
Journal Title
Journal ISSN
Volume Title
Publisher
Informa Healthcare
Abstract
The searching of protein databases as a method of identifying newly sequenced genes is commonplace in molecular biology laboratories. However, it is a procedure that is not usually formally taught to students, and method cookbooks discuss it only briefly.
This article uses a single family of highly diverged uracil-DNA glycosylases, which fall into two distinct groups, to highlight some of the difficulties associated with identification of such proteins by database searching.
Description
Keywords
Citation
Cattrel, K. et al. 1996. Approaches to Detection of Distantly Related Proteins by Database Searches. BioTechniques vol. 21, pp. 1118-1125.