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Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins?

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dc.contributor.author Wicki-Stordeur, Leigh E.
dc.contributor.author Swayne, Leigh Anne
dc.date.accessioned 2015-08-21T18:57:07Z
dc.date.available 2015-08-21T18:57:07Z
dc.date.copyright 2012 en_US
dc.date.issued 2012-04-27
dc.identifier.citation Wicki-Stordeur, L. & Swayne, L. 2012, "Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins?", STEM CELLS INTERNATIONAL, vol. 2012, Article ID 454180. en_US
dc.identifier.uri http://dx.doi.org/10.1155/2012/454180
dc.identifier.uri http://hdl.handle.net/1828/6470
dc.description.abstract The birth of new neurons from unspecialized neural stem and progenitor cells surrounding the lateral ventricles occurs throughout postnatal life. This process, termed neurogenesis, is complex and multistepped, encompassing several types of cellular behaviours, such as proliferation, differentiation, and migration. These behaviours are influenced by numerous factors present in the unique, permissive microenvironment. A major cellular mechanism for sensing the plethora of environmental cues directing this process is the presence of different channel forming proteins spanning the plasma membrane. So-called large pore membrane channels, which are selective for the passage of specific types of small molecules and ions, are emerging as an important subgroup of channel proteins. Here, we focus on the roles of three such large pore channels, aquaporin 4, connexin 43, and pannexin 1. We highlight both their independent functions as well as the accumulating evidence for crosstalk between them. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council of Canada; Victoria Foundation Willa and Ella Dawson Fund grant; University of Victoria en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.title Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins? en_US
dc.type Article en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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