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Fabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications

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dc.contributor.author Ko, Junghyuk
dc.contributor.author Mohtaram, Nima Khadem
dc.contributor.author Ahmed, Farid
dc.contributor.author Montgomery, Amy
dc.contributor.author Carlson, Michael
dc.contributor.author Lee, Patrick C.D.
dc.contributor.author Willerth, Stephanie
dc.contributor.author Jun, Martin B.G.
dc.date.accessioned 2016-05-24T12:31:35Z
dc.date.available 2016-05-24T12:31:35Z
dc.date.copyright 2014 en_US
dc.date.issued 2014
dc.identifier.citation Ko, J., Mohtaram, N.K., Ahmed, F., Montgomery, A., Carlson, M., Lee, P.C.D. … Jun, M.B.G. (2014). Fabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications. Journal of Biomaterials Science—Polymer Edition, 25(1), 1-17. en_US
dc.identifier.uri http://dx.doi.org/10.1080/09205063.2013.830913
dc.identifier.uri http://hdl.handle.net/1828/7315
dc.description.abstract Highly porous poly (ε-caprolactone) microfiber scaffolds can be fabricated using electrospinning for tissue engineering applications. Melt electrospinning produces such scaffolds by direct deposition of a polymer melt instead of dissolving the polymer in a solvent as performed during solution electrospinning. The objective of this study was to investigate the significant parameters associated with the melt electrospinning process that influence fiber diameter and scaffold morphology, including processing temperature, collection distance, applied voltage and nozzle size. The mechanical properties of these microfiber scaffolds varied with microfiber diameter. Additionally, the porosity of scaffolds was determined by combining experimental data with mathematical modeling. To test the cytocompatability of these fibrous scaffolds, we seeded neural progenitors derived from murine R1 embryonic stem cell lines onto these scaffolds where they could survive, migrate, and differentiate into neurons, demonstrating the potential of these melt electrospun scaffolds for tissue engineering applications. en_US
dc.description.sponsorship The authors would like to acknowledge support from Natural Sciences and Engineering Research Council (NSERC) Discovery Grants. They would also like to acknowledge the Advanced Microscopy Facility at the University of Victoria. en_US
dc.language.iso en en_US
dc.publisher Journal of Biomaterials Science—Polymer Edition en_US
dc.subject melt electrospinning en_US
dc.subject microfibers en_US
dc.subject micro structure en_US
dc.subject scaffolds en_US
dc.subject neural tissue engineering en_US
dc.subject stem cells en_US
dc.title Fabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications en_US
dc.type Postprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US


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