Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene

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dc.contributor.author Fukuhara, Gaku
dc.contributor.author Imai, Mami
dc.contributor.author Ishida, Yuki
dc.contributor.author Kurohara, Hiroki
dc.contributor.author Yang, Cheng
dc.contributor.author Mori, Tadashi
dc.contributor.author Uyama, Hiroshi
dc.contributor.author Cornelia, Bohne
dc.contributor.author Inouea, Yoshihisa
dc.contributor.author Fuentealba, Denis
dc.date.accessioned 2017-07-18T16:19:28Z
dc.date.copyright 2016 en_US
dc.date.issued 2016
dc.identifier.citation Fukuhara, Gaku et al. (2016). Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene. Organic & Biomolecular Chemistry, 14, 9741- 9750. doi 10.1039/C6OB01353H en_US
dc.identifier.uri doi 10.1039/C6OB01353H
dc.identifier.uri http://hdl.handle.net/1828/8351
dc.description.abstract Hybridizing natural macromolecule with synthetic polymer is an efficient general method for constructing sophisticated supramolecular architectures. To comprehensively elucidate the controversial hybridization mechanism of glucans with synthetic polymers, the hybridization behaviors of triple-stranded curdlan (Cur) and schizophyllan (SPG) with cationic polythiophene (PyPT) were investigated in aqueous DMSO solutions by using UV-vis, circular dichroism (CD), fluorescence, fluorescence excitation, and NMR spectroscopies, as well as theoretical calculations, dynamic light scattering, and zeta potential measurements. Upon mixing with glucan, a hetero-triplex formed was dynamic and greatly accelerated by heating and by adding base or salt. The hetero-triplex disassembled to hetero-duplex in highly basic solutions. Thus, polycationic polymers, such as PyPT, are expected to serve as a versatile tool for unzipping glucan homo-triplexes and promoting subsequent hybridization in aqueous solution, while the detailed mechanism elucidated in the present study contributes to the rational design of hybridization partners. en_US
dc.description.sponsorship This work was supported by Grant-in-Aid for Young Scientists (B) (No. 23750129), Challenging Exploratory Research (No. 26620061), and Young Scientists (A) (No. 16H06041) for GF and Grant-in-Aid for Scientific Research (A) (No. 21245011) and Challenging Exploratory Research (No. 26620030) for YI, all from Japan Society for the Promotion of Science (JSPS), and also by the grants for GF from The Ogasawara Foundation for the Promotion of Science & Engineering and Nakatani Foundation. CB thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support in the form of a Discovery Grant. CY thanks the National Natural Science Foundation of China for financial support (No. 21372165 and 23321061). en_US
dc.language.iso en en_US
dc.publisher Organic & Biomolecular Chemistry en_US
dc.title Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene en_US
dc.type Postprint en_US
dc.description.scholarlevel Faculty en_US
dc.description.reviewstatus Reviewed en_US
dc.description.embargo 2017-08-04

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