Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

Date

2020

Authors

Burke, John E.

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Volume Title

Publisher

EBioMedicine

Abstract

The synthesis and degradation of lipid phosphoinositides are fundamental in mediating signal transduction. Some of the most well studied phosphoinositide metabolising enzymes are the phospholipase C (PLC) family, which can hydrolyse the lipid phosphatidylinositol 4,5 bisphosphate (PIP2) into the signalling molecules inositol trisphosphate (IP3) and diacylglycerol [1]. There are multiple isoforms of the PLC family that are variably expressed in different cells/tissues, with each able to be activated downstream of a unique subset of cell surface receptors, including G-protein coupled receptors and tyrosine phosphorylated receptors. Recent years have revealed the myriad roles of a specific class of PLCs (PLCγ, encoded by the genes PLCG1 and PLCG2) in various human pathologies, including cancer [2,3], neurodegeneration [4], and immune disorders [5].

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Citation

Burke, J.E. (2020). Molecular insight into the autoinhibition of a master regulator of lipid signaling in human disease. EBioMedicine, 52(2020), 102634. https://doi.org/10.1016/j.ebiom.2020.102634