Synthetic Lipids for Drug Delivery Applications

dc.contributor.authorMeanwell, Michael Weiwei
dc.contributor.supervisorFyles, Thomas M.
dc.date.accessioned2015-09-23T20:35:57Z
dc.date.available2015-09-23T20:35:57Z
dc.date.copyright2015en_US
dc.date.issued2015-09-23
dc.degree.departmentDepartment of Chemistryen_US
dc.degree.levelMaster of Science M.Sc.en_US
dc.description.abstractSolid lipid nanoparticles (SLNPs) and lipid-drug conjugates (LDCs) are two promising lipid nanoparticle (LNP) based drug delivery systems; this thesis explores new synthetic lipids that may circumvent the limitations of currently available components for LNPs with particular focus on the stability of LNP formulations. Neutral polyethylene glycol lipids (PEG-lipids) have been designed, synthesized, and characterized with ESI-MS, for stabilizing SLNPs containing dsDNA oligomer. 1st and 2nd generation PEG-lipids investigated the effects of serinol and iminodiacetic acid backbone structures, respectively, and aliphatic chain sequences within the lipid anchors on the stability of SLNPs. Assays were developed to analyze LNP stability in both PBS buffer and PBS buffer with 10 % serum at different incubation temperatures. The results indicate that the hydrocarbon branching sequence offer additional SLNP stability over straight chain isomers. LDC monomers were designed and synthesized to allow for the formulation of LDC nanocarriers for the thiopurine drugs. These hydrophobic LDC monomers were made by linking the polar thiopurine drug to a synthetic lipid. These synthetic lipids investigated branched and straight chain derivatives – the branched isomers once again demonstrated advantages in the stability of the LDCs.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.urihttp://hdl.handle.net/1828/6714
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectDrug deliveryen_US
dc.subjectOrganic chemistryen_US
dc.subjectMedicinal chemistryen_US
dc.subjectSynthetic lipidsen_US
dc.subjectLipid nanoparticlesen_US
dc.subjectParticle stabilityen_US
dc.titleSynthetic Lipids for Drug Delivery Applicationsen_US
dc.typeThesisen_US

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