Sanchez-Arias, Juan C.Wicki-Stordeur, Leigh E.Candlish, Rebecca C.van der Slagt, EmmaPaci, IrinaRao, Praveen P. N.MacVicar, Brian A.Swayne, Leigh Anne2020-07-2220202020Sanchez Arias, J. C., Wicki-Stordeur, L. E., Candlish, R. C., van der Slagt, E. Paci, I., Rao, P. P. N., MacVicar, B. A., & Swayne, L. A. (2020). PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection. Cell Calcium, 90, 1-3. https://doi.org/10.1016/j.ceca.2020.102253.https://doi.org/10.1016/j.ceca.2020.102253http://hdl.handle.net/1828/11954A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.enendothelial cellsintracellular calciumpannexin 1TNF-alphaNF-kBcytokinestranscriptionIL-1betainflammationArticleDepartment of BiologyDepartment of Mathematics and Statistics