Saucier, Deborah2024-08-152024-08-1519901990https://hdl.handle.net/1828/19578The characteristics of the kindling of seizures produced by electrical stimulation of the nucleus accumbens (ventral striatum) or of the head, middle region, or tail of the caudate-putamen (dorsal striatum) were investigated in rats. Kindling in the accumbens group was characterized by high thresholds for afterdischarge (AD), forced movements during stimulation, slow progression from nonconvulsive to convulsive seizures, and large increases in the duration of the behavioral seizures. Kindling in the caudate groups was characterized by high AD thresholds, forced movements during stimulation, rapid progression from nonconvulsive to convulsive seizures, and small increases in the duration of the behavioral seizures. The similarities of striatal kindling to limbic and neocortical kindling are discussed, as are the relations of the present findings to previous evidence of striatal involvement in seizures.85 pagesAvailable to the World Wide WebThesis