Urdahl, Jasmin Violet2026-02-042026-02-042024https://hdl.handle.net/1828/23134The relationship between iron homeostasis and glucose metabolism has recently gained attention, as researchers attempt to uncover therapeutic approaches to treat type two diabetes. Type II diabetes mellitus (T2DM) is one of the most common endocrine disorders in the world. The prominence of hyperglycemic diets in Western countries has drastically increased the prevalence of T2DM. Both glucose and iron can act as biological stressors on cells, and result in increased production of reactive oxygen species (ROS). This can ultimately lead to pancreatic cell damage and impaired insulin signalling, as characterized by T2DM. Human ferritin, or the ortholog FTN- 1 in C. elegans, is an iron storage protein that plays a crucial role in mitigating oxidative stress caused by excess iron. In an attempt to elucidate physiological responses in iron metabolism to T2DM-like conditions, a unique C. elegans mutant worm was used, ftn-1penHonours thesisDepartment of Biology