Gao, ShashaBinod, PantChukwu, Chidozie WilliamsKwofie, TheophilusSafdar, SalmanNewman, LoraChoe, SeoyunDatta, Bimal KumarAttipoe, Wisdom KwameZhang, Wenjingvan den Driessche, P.2023-11-302023-11-3020232023Gao, S., Binod, P., Chukwu, C. W., Kwofie, T., Safdar, S., Newman, L., ... van den Driessche, P. (2023). A mathematical model to assess the impact of testing and isolation compliance on the transmission of COVID-19. Infectious Disease Modelling, 8(2), 427-444. https://doi.org/10.1016/j.idm.2023.04.005https://doi.org/10.1016/j.idm.2023.04.005http://hdl.handle.net/1828/15660The COVID-19 pandemic has ravaged global health and national economies worldwide. Testing and isolation are effective control strategies to mitigate the transmission of COVID-19, especially in the early stage of the disease outbreak. In this paper, we develop a deterministic model to investigate the impact of testing and compliance with isolation on the transmission of COVID-19. We derive the control reproduction number RC, which gives the threshold for disease elimination or prevalence. Using data from New York State in the early stage of the disease outbreak, we estimate RC=7.989. Both elasticity and sensitivity analyses show that testing and compliance with isolation are significant in reducing RC and disease prevalence. Simulation reveals that only high testing volume combined with a large proportion of individuals complying with isolation have great impact on mitigating the transmission. The testing starting date is also crucial: the earlier testing is implemented, the more impact it has on reducing the infection. The results obtained here would also be helpful in developing guidelines of early control strategies for pandemics similar to COVID-19.enCOVID-19TestingComplianceIsolationNew York stateArticle