Eggers, Paul Kahu2024-08-132024-08-1320012001https://hdl.handle.net/1828/17686A demacrocyclization design strategy for the creation of ion channel-forming compounds was explored. Beginning with an active bis-macrocyclic bola-amphiphile, two and four tailed acyclic bola-amphiphiles were identified. These target compounds were prepared by a modular synthetic approach based on ester and amide linking reactions resulting in an increased overall yield from previous macrocyclic compounds. Transport activity was measured by pH-stat titration methods. All three compounds exhibited significantly high activity. The compound containing central esters was clearly less active than the compounds containing central amides. All compounds are apparently strongly partitioned to a vesicle bilayer membrane.124 pagesAvailable to the World Wide WebThesis