Yeganegi, Arian2023-08-102023-08-1020232023-08-10http://hdl.handle.net/1828/15249This thesis presents the development of a proof-of-concept sensor for the sensitive and selective detection of Trans-Δ⁹-tetrahydrocannabinol (THC) using a molecularly imprinted polymer (MIP) synthesized with a THC template. The sensor combines MIP technology with Raman spectroscopy to achieve label-free monitoring of THC based on a single identifying Raman peak. The MIP sensor exhibits a prominent peak at 1614 cm-1 in the Raman spectrum, attributed to the THC target molecule, enabling the selective quantification of bound THC with a low detection limit of 250 ppm. Comparative studies with a non-imprinted polymer (NIP) control demonstrate higher sensitivity of the MIP to the THC target molecule (67% higher average intensity), confirming the presence of THC-specific recognition sites within the synthesized MIP material. Additionally, the selectivity of the MIP-based sensor is demonstrated by analyzing the Raman spectrum of MIP exposed to Cannabidiol (CBD), ethanol, and acetone.enAvailable to the World Wide WebMolecularly imprinted polymer (MIP)Raman spectroscopyTHC detectionThesis