Altman, Irwin Morris2024-08-122024-08-1219821982https://hdl.handle.net/1828/16950The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline (arbitrarily defined as greater than 80%) significantly facilitated the rate of kindling of cortico-generalized seizures. In contrast, a group of 6-OHDA-treated rats that showed minimal depletion of noradrenaline (arbitrarily defined as 80% or less) appeared to develop generalized seizures at a slower rate than controls. The present findings extend previous observations that 6-OHDA-induced depletion of noradrenaline facilitates amygdaloid kindling, by demonstrating that cortical kindling is similarly affected.46 pagesAvailable to the World Wide WebThesis