Design and CT imaging of casper, an anthropomorphic breathing thorax phantom

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dc.contributor.authorLaidlaw, Josie
dc.contributor.authorEarl, Nicolas
dc.contributor.authorShavdia, Nihal
dc.contributor.authorDavis, Rayna
dc.contributor.authorMayer, Sarah
dc.contributor.authorKaraman, Dmitri
dc.contributor.authorRichtsmeier, Devon
dc.contributor.authorRodesch, Pierre-Antoine
dc.contributor.authorBazalova-Carter, Magdalena
dc.date.accessioned2023-07-04T16:26:04Z
dc.date.available2023-07-04T16:26:04Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.description.abstractThe goal of this work was to build an anthropomorphic thorax phantom capable of breathing motion with materials mimicking human tissues in x-ray imaging applications. The thorax phantom, named Casper, was composed of resin (body), foam (lungs), glow polyactic acid (bones) and natural polyactic acid (tumours placed in the lungs). X-ray attenuation properties of all materials prior to manufacturing were evaluated by means of photon-counting computed tomography (CT) imaging on a table-top system. Breathing motion was achieved by a scotch-yoke mechanism with diaphragm motion frequencies of 10−20 rpm and displacements of 1 to 2 cm. Casper was manufactured by means of 3D printing of moulds and ribs and assembled in a complex process. The final phantom was then scanned using a clinical CT scanner to evaluate material CT numbers and the extent of tumour motion. Casper CT numbers were close to human CT numbers for soft tissue (46 HU), ribs (125 HU), lungs (−840 HU) and tumours (−45 HU). For a 2 cm diaphragm displacement the largest tumour displacement was 0.7 cm. The five tumour volumes were accurately assessed in the static CT images with a mean absolute error of 4.3%. Tumour sizes were either underestimated for smaller tumours or overestimated for larger tumours in dynamic CT images due to motion blurring with a mean absolute difference from true volumes of 10.3%. More Casper information including a motion movie and manufacturing data can be downloaded from http://web.uvic.ca/~bazalova/Casper/.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was partially funded by an NSERC Dis covery Grant and CGS D scholarship, by the Canada Research Chairs program, Canada Foundation for Innovation and British Columbia Knowledge and Development Fund. We would like to thank Teaghan O’Briain for his help with XCAT phantom processing and to Clay Lindsay for help with CT scanning.en_US
dc.identifier.citationLaidlaw, J., Earl, N., Shavdia, N., Davis, R., Mayer, S., Karaman, D., Richtsmeier, D., Rodesch, P.-A., & Bazalova-Carter, M. (2023). Design and CT imaging of casper, an anthropomorphic breathing thorax phantom. Biomedical Physics & Engineering Express, 9(2), 025008. https://doi.org/10.1088/2057-1976/acb7f7en_US
dc.identifier.urihttps://doi.org/10.1088/2057-1976/acb7f7
dc.identifier.urihttp://hdl.handle.net/1828/15175
dc.language.isoenen_US
dc.publisherBiomedical Physics & Engineering Expressen_US
dc.titleDesign and CT imaging of casper, an anthropomorphic breathing thorax phantomen_US
dc.typeArticleen_US

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