Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease

Date

2013-09-30

Authors

Simpson, Jessica M.

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Abstract

Alterations in both structural and synaptic plasticity in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated if hippocampal plasticity is affected in the transgenic YAC128 mouse model of Huntington disease (HD). Reductions in adult hippocampal neurogenesis were observed in the dentate gyrus (DG) of early symptomatic to end-stage mice compared with wild-type (WT) controls, however there were no changes in cell proliferation and differentiation in the subventricular zone. Early symptomatic mice also displayed attenuated paired-pulse plasticity and long-term depression in the DG, while long-term potentiation was found to be normal in YAC128 mice. The changes in hippocampal plasticity may contribute to the cognitive abnormalities observed in these animals.

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Keywords

Huntington's chorea, Hippocampus

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