Monte Carlo optimization of a GRID collimator for preclinical megavoltage ultra-high dose rate spatially-fractionated radiation therapy
| dc.contributor.author | Clements, Nathan | |
| dc.contributor.author | Bazalova-Carter, Magdalena | |
| dc.contributor.author | Esplen, Nolan | |
| dc.date.accessioned | 2023-03-30T20:34:50Z | |
| dc.date.available | 2023-03-30T20:34:50Z | |
| dc.date.copyright | 2022 | en_US |
| dc.date.issued | 2022-09-07 | |
| dc.description.abstract | Objective. A 2-dimensional pre-clinical SFRT (GRID) collimator was designed for use on the ultra-high dose rate (UHDR) 10 MV ARIEL beamline at TRIUMF. TOPAS Monte Carlo simulations were used to determine optimal collimator geometry with respect to various dosimetric quantities. Approach. The GRID-averaged peak-to-valley dose ratio (PVDR) and mean dose rate of the peaks were investigated with the intent of maximizing both values in a given design. The effects of collimator thickness, focus position, septal width, and hole width on these metrics were found by testing a range of values for each parameter on a cylindrical GRID collimator. For each tested collimator geometry, photon beams with energies of 10, 5, and 1 MV were transported through the collimator and dose rates were calculated at various depths in a water phantom located 1.0 cm from the collimator exit. Main results. In our optimization, hole width proved to be the only collimator parameter which increased both PVDR and peak dose rates. From the optimization results, it was determined that our optimized design would be one which achieves the maximum dose rate for a PVDR $\geqslant 5$ at 10 MV. Ultimately, this was achieved using a collimator with a thickness of 75 mm, 0.8 mm septal and hole widths, and a focus position matched to the beam divergence. This optimized collimator maintained the PVDR of 5 in the phantom between water depths of 0–10 cm at 10 MV and had a mean peak dose rate of $3.06\pm 0.02$ ${\rm{Gy}}\,{{\rm{s}}}^{-1}$ at 0–1 cm depth. Significance. We have investigated the impact of various GRID-collimator design parameters on the dose rate and spatial fractionation of 10, 5, and 1 MV photon beams. The optimized collimator design for the 10 MV ultra-high dose rate photon beam could become a useful tool for radiobiology studies synergizing the effects of ultra-high dose rate (FLASH) delivery and spatial fractionation. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | This work was funded in part by an NSERC Discovery grant as well as the Canada Research Chairs program. This research was enabled in part by support provided by WestGrid (www.westgrid.ca) and Compute Canada (www.computecanada.ca). | en_US |
| dc.identifier.citation | Clements, N., Bazalova-Carter, M., & Esplen, N. (2022). Monte Carlo optimization of a GRID collimator for preclinical megavoltage ultra-high dose rate spatially-fractionated radiation therapy. Physics in Medicine & Biology, 67(18), 185001. https://doi.org/10.1088/1361-6560/ac8c1a | en_US |
| dc.identifier.uri | https://doi.org/10.1088/1361-6560/ac8c1a | |
| dc.identifier.uri | http://hdl.handle.net/1828/14927 | |
| dc.language.iso | en | en_US |
| dc.publisher | Physics in Medicine & Biology | en_US |
| dc.subject | GRID | en_US |
| dc.subject | spatially-fractionated radiation therapy | en_US |
| dc.subject | optimization | en_US |
| dc.subject | collimator | en_US |
| dc.subject | Monte Carlo | en_US |
| dc.subject | dosimetry | en_US |
| dc.title | Monte Carlo optimization of a GRID collimator for preclinical megavoltage ultra-high dose rate spatially-fractionated radiation therapy | en_US |
| dc.type | Article | en_US |