Pathway representation using finite state automata and comparison using the NCI thesaurus
| dc.contributor.author | Leung, Samuel | |
| dc.contributor.supervisor | Kapron, Bruce | |
| dc.date.accessioned | 2010-02-16T17:16:17Z | |
| dc.date.available | 2010-02-16T17:16:17Z | |
| dc.date.copyright | 2006 | en |
| dc.date.issued | 2010-02-16T17:16:17Z | |
| dc.degree.department | Department of Computer Science | |
| dc.degree.level | Master of Science M.Sc. | en |
| dc.description.abstract | Can one classify biochemical pathways based on their topology? What is the topology of a biochemical pathway? What are the fundamental principles underlying different biochemical pathways involved in similar functional areas? Will one be able to characterize pathway "motifs" similar to motifs in proteins - i.e. reoccurring patterns in pathways? This thesis describes an attempt to develop a quantitative framework for the general representation and comparison of biochemical pathways. This quantitative framework involves a mathematical model to represent biochemical pathways and a set of similarity criteria to compare these biochemical pathways. We anticipate that such a tool would allow biologists to answer important questions such as the ones mentioned above. | en |
| dc.identifier.uri | http://hdl.handle.net/1828/2200 | |
| dc.language | English | eng |
| dc.language.iso | en | en |
| dc.rights | Available to the World Wide Web | en |
| dc.subject | biochemistry | en |
| dc.subject | bioinformatics | en |
| dc.subject | mathematical models | en |
| dc.subject.lcsh | UVic Subject Index::Sciences and Engineering::Chemistry::Biochemistry | en |
| dc.subject.lcsh | UVic Subject Index::Sciences and Engineering::Applied Sciences::Computer science | en |
| dc.title | Pathway representation using finite state automata and comparison using the NCI thesaurus | en |
| dc.type | Thesis | en |