Multiple layers of inhibition in the direction coding circuit in mouse retina

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dc.contributor.authorHoggarth, K. Alex
dc.contributor.supervisorAwatramani, Gautam
dc.date.accessioned2016-08-15T14:58:23Z
dc.date.available2016-08-15T14:58:23Z
dc.date.copyright2016en_US
dc.date.issued2016-08-15
dc.degree.departmentDepartment of Biology
dc.degree.levelMaster of Science M.Sc.en_US
dc.description.abstractLocal and global forms of inhibition control directionally selective ganglion cells (DSGCs) in the mammalian retina. Specifically, local inhibition arising from GABAergic starburst amacrine cells (SACs) strongly contributes to direction selectivity. In this thesis, I demonstrate that increasing ambient illumination leads to the recruitment of GABAergic wide-field amacrine cells (WACs) endowing the DS circuit with an additional feature: size selectivity. Using a combination of electrophysiology, pharmacology and light/electron microscopy, I demonstrate that WACs predominantly contact presynaptic bipolar cells, which drive direct excitation and feed-forward inhibition (through SACs) to DSGCs, therefore maintaining the appropriate balance of inhibition/excitation required for generating DS. This circuit arrangement permits high-fidelity direction coding over a range of ambient light levels, over which size selectivity is adjusted. Together, these results provide novel insights into the anatomical and functional arrangement of multiple inhibitory interneurons within a single computational module in the retina.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationHoggarth A, et al., (2015) Specific wiring of distinct amacrine cells in the directionally selective retinal circuit permits independent coding of direction and size. Neuron. 8;86(1):276-91en_US
dc.identifier.urihttp://hdl.handle.net/1828/7432
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectretinaen_US
dc.subjectamacrine cellen_US
dc.subjectvisionen_US
dc.subjectmouseen_US
dc.subjectsurround inhibitionen_US
dc.subjectspatiotemporal tuningen_US
dc.titleMultiple layers of inhibition in the direction coding circuit in mouse retinaen_US
dc.typeThesisen_US

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