Low-frequency stimulation inducible long-term potentiation at the accessory olfactory bulb to medial amygdala synapse of the American Bullfrog

Simple item page
dc.contributor.authordeRosenroll, Geoff
dc.contributor.supervisorDelaney, Kerry R.
dc.date.accessioned2016-02-22T19:46:33Z
dc.date.available2016-10-02T11:22:10Z
dc.date.copyright2015en_US
dc.date.issued2016-02-22
dc.degree.departmentProgram: Neuroscienceen_US
dc.degree.levelMaster of Science M.Sc.en_US
dc.description.abstractThe mitral cells of the accessory olfactory bulb (AOB) of anuran frogs project their axons directly to the medial amygdala (MeA) along the accessory olfactory tract. An en bloc preparation of the telencephalon of the American bullfrog Lithobates catesbeiana was utilized to study a form of low-frequency inducible long-term potentiation (LTP) expressed at the synapse formed between the terminals of the accessory olfactory tract and the neurons of the MeA. Delivery of repetitive 1Hz-stimulation or sets of 5Hz tetani to the accessory olfactory tract both induced potentiation that was stable for over an hour, as measured by extracellular field recordings. LTP induced by 5Hz tetanus was associated with a decrease in paired-pulse ratio, which would be consistent with an increased probability of release contributing to the increased synaptic strength. Blockade of neither NMDA nor kainate glutamate receptors, with AP5 and UBP310 respectively, prevented LTP induction by 5Hz tetanus; however expression of LTP was partially masked in the presence of UBP310. These results suggest that kainate receptors are involved in the expression of LTP at the AOB-MeA synapse, though the means by which LTP is induced remains unclear.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.urihttp://hdl.handle.net/1828/7061
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectneuroscienceen_US
dc.subjectsynaptic plasticityen_US
dc.subjectLTPen_US
dc.subjectphysiologyen_US
dc.subjectbullfrogen_US
dc.subjectamygdalaen_US
dc.subjectaccessory olfactory systemen_US
dc.titleLow-frequency stimulation inducible long-term potentiation at the accessory olfactory bulb to medial amygdala synapse of the American Bullfrogen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
deRosenroll_Geoff_MSc_2015.pdf
Size:
1.81 MB
Format:
Adobe Portable Document Format
Description:
MSc Thesis
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.74 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Electronic Theses and Dissertations (ETD)
Theses (Neuroscience)
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.