Polymeric Nanoparticles for Drug Delivery: Exploring the Co-Encapsulation of SN-38 and Curcumin

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dc.contributor.authorCazelais, Amélie
dc.date.accessioned2022-09-07T21:22:22Z
dc.date.available2022-09-07T21:22:22Z
dc.date.copyright2022en_US
dc.date.issued2022-09-07
dc.description.abstractIrinotecan is widely used clinically as an anticancer treatment. The active component, SN-38, is used in research, but with limited clinical uses due to factors including low water solubility, and the molecule’s inactivity above a pH of 6. Using the active form of the drug has many advantages. However, SN-38’s hydrophobicity is an issue. The use of polymer nanoparticles (PNPs) can be explored to encapsulate SN-38 in their hydrophobic cores, possibly leading to further clinical uses. PNPs were made by nanoprecipitation using a microfluidic reactor, then were characterized for morphology, size, and drug content. Encapsulation of SN-38 would solve the problem of hydrophobicity but is difficult to achieve. The research explores the increase in encapsulation efficiency of SN-38 PNPs co-loaded with curcumin, a compound from turmeric, compared to SN-38 PNPs alone.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelUndergraduateen_US
dc.description.sponsorshipValerie Kuehne Undergraduate Research Awards (VKURA)en_US
dc.identifier.urihttp://hdl.handle.net/1828/14201
dc.language.isoenen_US
dc.subjectcurcumin
dc.subjectdynamic light scattering (DLS)
dc.subjecthigh-performance liquid chromatography (HPLC)
dc.subjectirinotecan
dc.subjectmicrofluidics
dc.subjectnanoprecipitation
dc.subjectN,N-dimethylformamide (DMF)
dc.subjectpoly(?- caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG)
dc.subjectpolydispersity
dc.subjectpolymer nanoparticles (PNPs)
dc.subjectrotary evaporation
dc.subjectSN-38
dc.subjectValerie Kuehne Undergraduate Research Awards (VKURA)
dc.subject.departmentDepartment of Chemistry
dc.titlePolymeric Nanoparticles for Drug Delivery: Exploring the Co-Encapsulation of SN-38 and Curcuminen_US
dc.typePosteren_US

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