Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence

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dc.contributor.authorRico-Barrio, Irantzu
dc.contributor.authorPeñasco, Sara
dc.contributor.authorLekunberri, Leire
dc.contributor.authorSerrano, Maitane
dc.contributor.authorEgaña-Huguet, Jon
dc.contributor.authorMimenza, Amaia
dc.contributor.authorSoria-Gomez, Edgar
dc.contributor.authorRamos, Almudena
dc.contributor.authorBuceta, Ianire
dc.contributor.authorGerrikagoitia, Immaculada
dc.contributor.authorMendizabal-Zubiaga, Juan
dc.contributor.authorElezgarai, Izaskun
dc.contributor.authorPuente, Nagore
dc.contributor.authorGrandes, Pedro
dc.date.accessioned2021-08-09T21:08:27Z
dc.date.available2021-08-09T21:08:27Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractBinge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers memory in mice after adolescent BD, and the endocannabinoid, 2-arachydonoyl-glycerol (2-AG), rescues synaptic plasticity and memory impaired in adult rodents upon adolescent EtOH intake. However, the mechanisms by which EE improves memory are unknown. We investigated this in adolescent male C57BL/6J mice exposed to a drinking in the dark (DID) procedure four days per week for a duration of 4 weeks. After DID, the mice were nurtured under an EE for 2 weeks and were subjected to the Barnes Maze Test performed the last 5 days of withdrawal. The EE rescued memory and restored the EtOH-disrupted endocannabinoid (eCB)-dependent excitatory long-term depression at the dentate medial perforant path synapses (MPP-LTD). This recovery was dependent on both the cannabinoid CB1 receptor and group I metabotropic glutamate receptors (mGluRs) and required 2-AG. Also, the EE had a positive effect on mice exposed to water through the transient receptor potential vanilloid 1 (TRPV1) and anandamide (AEA)-dependent MPP long-term potentiation (MPP-LTP). Taken together, EE positively impacts different forms of excitatory synaptic plasticity in water- and EtOH-exposed brains.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was funded by ISCIII (“RD16/0017/0012” to P.G.), co-funded by ERDF/ESF, “Investing in your future”; The Basque Government (IT1230-19 to P.G.); Ministry of Science and Innovation (PID2019-107548RB-I00 to P.G.); Ph.D. contract from MINECO (BES-2013-065057 to S.P.); Ph.D. contract from UPV/EHU (PIF 18/315 to L.L.), and Ph.D. contract from UPV/EHU (PIF 19/164 to M.S.).en_US
dc.identifier.citationRico-Barrio, I., Peñasco, S., Lekunberri, L., Serrano, M., Egaña-Huguet, J., Mimenza, A., … Grandes, P. (2021). Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence. Biomedicines, 9(7), 1-14. https://doi.org/10.3390/biomedicines9070825.en_US
dc.identifier.urihttps://doi.org/10.3390/biomedicines9070825
dc.identifier.urihttp://hdl.handle.net/1828/13224
dc.language.isoenen_US
dc.publisherBiomedicinesen_US
dc.subjectendocannabinoid systemen_US
dc.subjectsynaptic plasticityen_US
dc.subjectmemoryen_US
dc.subjectdrug addictionen_US
dc.subjectenrichment therapyen_US
dc.titleEnvironmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescenceen_US
dc.typeArticleen_US

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