Genetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insect

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dc.contributor.authorHamilton, Phineas T.
dc.contributor.authorHodson, Christina N.
dc.contributor.authorCurtis, Caitlin I.
dc.contributor.authorPerlman, Steve
dc.date.accessioned2019-09-18T22:13:20Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.description.abstractDiverse selfish genetic elements have evolved the ability to manipulate reproduction to increase their transmission, and this can result in highly distorted sex ratios [1]. Indeed, one of the major explanations for why sex determination systems are so dynamic is because they are shaped by ongoing coevolutionary arms races between sex-ratio-distorting elements and the rest of the genome [2]. Here, we use genetic crosses and genome analysis to describe an unusual sex ratio distortion with striking consequences on genome organization in a booklouse species, Liposcelis sp. (Insecta: Psocodea), in which two types of females coexist. Distorter females never produce sons but must mate with males (the sons of nondistorting females) to reproduce [3]. Although they are diploid and express the genes inherited from their fathers in somatic tissues, distorter females only ever transmit genes inherited from their mothers. As a result, distorter females have unusual chimeric genomes, with distorter-restricted chromosomes diverging from their nondistorting counterparts and exhibiting features of a giant non-recombining sex chromosome. The distorter-restricted genome has also acquired a gene from the bacterium Wolbachia, a well-known insect reproductive manipulator; we found that this gene has independently colonized the genomes of two other insect species with unusual reproductive systems, suggesting possible roles in sex ratio distortion in this remarkable genetic system.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was funded by an Natural Sciences and Engineering Research Council (NSERC) Discovery Grant to S.J.P. S.J.P. also acknowledges support from the Canadian Institute for Advanced Research’s Integrated Microbial Biodiversity Program. We thank Compute Canada for access to computational resources that enabled this study and Jong Leong and David Minkley for method discussion and advice. P.T.H. is supported by a Canadian Institutes of Health Research (CIHR) postdoctoral fellowship.en_US
dc.identifier.citationHamilton, P.T., Hodson, C.N., Curtis, C.I. & Perlman, S.J. (2018). Genetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insect. Current Biology, 28(23), 3864-3870.e4. https://doi.org/10.1016/j.cub.2018.10.035en_US
dc.identifier.urihttps://doi.org/10.1016/j.cub.2018.10.035
dc.identifier.urihttp://hdl.handle.net/1828/11157
dc.language.isoenen_US
dc.publisherCurrent Biologyen_US
dc.subjectsex ratioen_US
dc.subjectWolbachiaen_US
dc.subjectpaternal genome eliminationen_US
dc.subjectselfish genetic elementsen_US
dc.subjectgenetic conflicten_US
dc.subjectsex determinationen_US
dc.subjectliceen_US
dc.subjectbookliceen_US
dc.titleGenetics and Genomics of an Unusual Selfish Sex Ratio Distortion in an Insecten_US
dc.typePreprinten_US

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