Design and Testing of Safer, More Effective Preservatives for Consumer Products

Simple item page
dc.contributor.authorBuckley, Heather L.
dc.contributor.authorHart-Cooper, William M.
dc.contributor.authorKim, Jong H.
dc.contributor.authorFaulkner, David M.
dc.contributor.authorCheng, Luisa W.
dc.contributor.authorChan, Kathleen L.
dc.contributor.authorVulpe, Christopher D.
dc.contributor.authorOrts, William J.
dc.contributor.authorAmrose, Susan E.
dc.contributor.authorMulvihill, Martin J.
dc.date.accessioned2021-03-08T19:05:15Z
dc.date.available2021-03-08T19:05:15Z
dc.date.copyright2017en_US
dc.date.issued2017
dc.description.abstractPreservatives deter microbial growth, providing crucial functions of safety and durability in composite materials, formulated products, and food packaging. Concern for human health and the environmental impact of some preservatives has led to regulatory restrictions and public pressure to remove individual classes of compounds, such as parabens and chromated copper arsenate, from consumer products. Bans do not address the need for safe, effective alternative preservatives, which are critical for both product performance (including lifespan and therefore life cycle metrics) and consumer safety. In this work, we studied both the safety and efficacy of a series of phenolic preservatives and compared them to common preservatives found in personal care products and building materials. We quantified antimicrobial activity against Aspergillus brasiliensis (mold) and Pseudomonas aeruginosa (Gram negative bacteria), and we conducted a hazard assessment, complemented by computational modeling, to evaluate the human and environmental health impacts of these chemicals. We found that octyl gallate demonstrates better antimicrobial activity and comparable or lower hazards, compared to current-use preservatives. Therefore, octyl gallate may serve as a viable small-molecule preservative, particularly in conjunction with low concentrations of other preservatives that act through complementary mechanisms.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationBuckley, H. L., Hart-Cooper, W. M., Kim, J. H., Faulkner, D. M., Cheng, L. W., Chan, K. L…Mulvihill, M. J. (2017). Design and Testing of Safer, More Effective Preservatives for Consumer Products, ACS Sustainable Chemistry & Engineering, 5(5), 4320–4331. https://doi.org/10.1021/acssuschemeng.7b00374en_US
dc.identifier.urihttps://doi.org/10.1021/acssuschemeng.7b00374
dc.identifier.urihttp://hdl.handle.net/1828/12757
dc.language.isoenen_US
dc.publisherACS Sustainable Chemistry & Engineeringen_US
dc.subjectPreservativeen_US
dc.subjectAntimicrobialen_US
dc.subjectSafer alternativeen_US
dc.subjectOctyl gallateen_US
dc.subjectConsumer productsen_US
dc.subjectHazard assessmenten_US
dc.subjectComputational toxicologyen_US
dc.titleDesign and Testing of Safer, More Effective Preservatives for Consumer Productsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Buckley_Heather_ACSJCA_2017.pdf
Size:
1.78 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty Publications (Engineering and Computer Science)
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.