Establishing a Co-infection Model between Seasonal Human Coronaviruses and Staphylococcus aureus
| dc.contributor.author | Nickel, Karen | |
| dc.date.accessioned | 2025-05-08T14:21:24Z | |
| dc.date.available | 2025-05-08T14:21:24Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Coronaviruses usually cause the common cold, but upon secondary infection with the bacterium Staphylococcus aureus, increased morbidity and mortality rates are observed. Notably, a significant complication of severe COVID-19 disease, caused by SARS-CoV-2, has been co-infection with the bacterium S. aureus. In these cases, while co-infection did not impact S. aureus growth, it led to significant pro-viral effects. The S. aureus iron-regulated surface determinant A (IsdA) protein contributed to the increase in viral titre by altering JAK2-STAT3 levels and modifying host transcription. 229E and OC43 are two seasonal human coronaviruses which are generally responsible for mild upper respiratory tract infections. Co-infection with S. aureus has been detected following their infection, but little is known about the impacts of S. aureus on viral replication, or vice versa. My research aims to investigate these relationships using an in vitro co-infection model. This research may contribute to our understanding of coronavirus and Staphylococcus aureus co-infections, which in turn may help develop better treatment strategies. | |
| dc.description.reviewstatus | Reviewed | |
| dc.description.scholarlevel | Undergraduate | |
| dc.description.sponsorship | Jamie Cassels Undergraduate Research Awards (JCURA) | |
| dc.identifier.uri | https://hdl.handle.net/1828/22192 | |
| dc.publisher | University Of Victoria | |
| dc.subject | co-infection | |
| dc.subject | coronavirus | |
| dc.subject | S. aureus | |
| dc.subject | virus | |
| dc.subject | infection | |
| dc.title | Establishing a Co-infection Model between Seasonal Human Coronaviruses and Staphylococcus aureus | |
| dc.type | Poster |