Event-related potential correlates of catecholinergic neuromodulators norepinephrine and dopamine
| dc.contributor.author | Warren, Christopher Michael | |
| dc.contributor.supervisor | Holroyd, Clay Brian | |
| dc.date.accessioned | 2011-12-22T23:53:16Z | |
| dc.date.available | 2011-12-22T23:53:16Z | |
| dc.date.copyright | 2011 | en_US |
| dc.date.issued | 2011-12-22 | |
| dc.degree.department | Dept. of Psychology | en_US |
| dc.degree.level | Doctor of Philosophy Ph.D. | en_US |
| dc.description.abstract | Adaptive decision making depends on multiple processes, including fast and efficient processing of stimulus events for effective responding and slow trial-to-trial learning of action values for optimization of the selection process. I applied the event-related brain potential (ERP) technique to investigate the involvement of two neuromodulatory systems in learning and decision making: The locus coeruleus-norepinephrine (LC-NE) system and the mesencephalic dopamine system (DA system). I present evidence that the "oddball" N2, a negative deflection in the ERP elicited by task-relevant events that begins approximately 200 ms after onset of the eliciting stimulus and that is sensitive to low-probability events, is a manifestation of cortex-wide noradrenergic modulation recruited to facilitate the processing of unexpected stimuli. Further, Holroyd and Coles (2002) proposed that the impact of DA reinforcement learning signals on the anterior cingulate cortex (ACC) produces a component of the ERP called the feedback-related negativity (FRN). I present electroencephalographic evidence that both the DA system and the LC-NE system act in concert when learning from rewards that vary in expectedness, but that the DA system is relatively more exercised when subjects are highly engaged/challenged by learning tasks, whereas the impact of the LC-NE system is attenuated by this manipulation. | en_US |
| dc.description.scholarlevel | Graduate | en_US |
| dc.identifier.uri | http://hdl.handle.net/1828/3773 | |
| dc.language | English | eng |
| dc.language.iso | en | en_US |
| dc.rights.temp | Available to the World Wide Web | en_US |
| dc.subject | locus coeruleus | en_US |
| dc.subject | norepinephrine | en_US |
| dc.subject | dopamine | en_US |
| dc.subject | event-related potential | en_US |
| dc.subject | N2 | en_US |
| dc.subject | fERN | en_US |
| dc.subject | learning | en_US |
| dc.subject | attention | en_US |
| dc.title | Event-related potential correlates of catecholinergic neuromodulators norepinephrine and dopamine | en_US |
| dc.type | Thesis | en_US |