Discovering the Biochemical Properties and Antigen Targets of Tumour-Infiltrating B Lymphocyte Antibodies

Simple item page
dc.contributor.authorDedora, Jaden
dc.date.accessioned2023-03-19T07:18:50Z
dc.date.available2023-03-19T07:18:50Z
dc.date.copyright2023en_US
dc.date.issued2023-03-19
dc.description.abstractImmunotherapies using T cells have had fantastic success in hematological malignancies or blood cancers, but the treatment has yet to prove effective for solid tumours. To improve the effectiveness of immunotherapies, we need to harness other powerful immune cells, like tumour-infiltrating B cells (TIL-B). Indeed, TIL-B and their antibodies are associated with prolonged patient survival in several cancers, yet their antigen targets and exact mechanisms remain poorly understood. We seek to understand what these antibodies do and what they are binding in the tumour environment. We hypothesize that TIL-B plays a critical role in anti-tumour immunity by producing antibodies that recognize tumour-relevant antigens and mediate various immunological effects. We found that highly reactive antibodies have shorter binding sites than weakly reactive antibodies. As well we found using rAscal (recombinant antibody screening of cDNA antigen library) that a TIL-B antibody binds histone 2 variant 1, a nuclear protein. As we continue to learn more about the antigen targets, we will decipher the role of TIL-B in the anti-tumour response, which will advance the next generation of immunotherapies.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelUndergraduateen_US
dc.description.sponsorshipJamie Cassels Undergraduate Research Awards (JCURA)en_US
dc.identifier.urihttp://hdl.handle.net/1828/14896
dc.language.isoenen_US
dc.subjectovarian canceren_US
dc.subjectantigen identificationen_US
dc.subjectTumour-infiltrating B lymphocytesen_US
dc.subjectB cellsen_US
dc.subjectImmunotherapyen_US
dc.titleDiscovering the Biochemical Properties and Antigen Targets of Tumour-Infiltrating B Lymphocyte Antibodiesen_US
dc.typePosteren_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Jaden Dedora-JCURAposter-2023.pdf
Size:
1.26 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Jamie Cassels Undergraduate Research Awards (JCURA)
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.