Comparative responses of salmon to sea lice Lepeophtheirus salmonis infections, and lice responses to chemical and environmental stressors

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dc.contributor.authorSutherland, Ben James Gerard
dc.contributor.supervisorKoop, Benjamin F.
dc.date.accessioned2014-05-29T17:32:39Z
dc.date.available2014-05-29T17:32:39Z
dc.date.copyright2014en_US
dc.date.issued2014-05-29
dc.degree.departmentDepartment of Biology
dc.degree.levelDoctor of Philosophy Ph.D.en_US
dc.description.abstractSystems biology methods can provide novel insight into the responses of an organism to a suboptimal environment, an infection or exposure to a xenobiotic. In the interaction of salmon and salmon lice, there are several areas requiring further research. These include the impacts of lice infection on wild salmon, response mechanisms of different salmon species or life stages to lice infections, effects of environmental conditions on lice stress, and mechanisms underlying the emergence of resistance to important parasiticidal chemicals. Here, I combine global gene expression analyses with phenotypic and physiological responses of salmon or salmon lice to further our understanding of these topics. In the first chapter, I introduce the work by discussing relevant background material on the current knowledge of salmon and salmon lice interactions, salmon immunity, the state of salmon and louse genomics and the emerging field of ecological genomics. I also discuss how these approaches are applied to the study of non-model organisms and sustainable aquaculture development and fisheries conservation. In the second chapter, I present the first large-scale transcriptome profiling of a Pacific salmon to a salmon lice infection, identifying transcript signatures associated with an infection in a sensitive life stage of pink salmon Oncorhynchus gorbuscha. In the third chapter, I present the results of multiple co-habitation infections of three species of Pacific and Atlantic salmon to compare physiological and transcriptomic responses at the local (skin) and systemic levels (anterior kidney). In the fourth chapter, I explore louse transcriptome functioning during temperature and salinity perturbations to characterize the molecular stress response and coping strategies of lice, as well as provide stressor context to response genes. In the fifth chapter, I evaluate sensitive Pacific and resistant and sensitive Atlantic lice responses to emamectin benzoate, an important compound for louse control which has recently been evaded by the louse through resistance development in multiple regions worldwide. In the sixth and final chapter, I conclude with a synthesis of what was learned about knowledge gaps discussed above and how to best apply this information by providing some approaches for future research to address remaining challenges.en_US
dc.description.proquestcode0369en_US
dc.description.proquestcode0792en_US
dc.description.proquestcode0718en_US
dc.description.proquestemailbensutherland7@gmail.comen_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationSutherland BJG, Koczka KW, Yasuike M, Jantzen SG, Yazawa, R, Koop BF and Jones SRM (2014). Comparative transcriptomics of Atlantic Salmo salar, chum Oncorhynchus keta and pink salmon O. gorbuscha during infections with salmon lice Lepeophtheirus salmonis. BMC Genomics 15, 200.en_US
dc.identifier.bibliographicCitationSutherland BJG, Jantzen SG, Yasuike M, Sanderson DS, Koop BF, Jones SRM (2012). Transcriptomics of coping strategies in free-swimming Lepeophtheirus salmonis (Copepoda) larvae responding to abiotic stress. Molecular Ecology 21, 6000-6014.en_US
dc.identifier.bibliographicCitationSutherland BJG, Jantzen SG, Sanderson DS, Koop BF, Jones SRM (2011). Differentiating size-dependent responses of juvenile pink salmon (Oncorhynchus gorbuscha) to sea lice (Lepeophtheirus salmonis) infections. Comparative Biochemistry and Physiology D- Genomics & Proteomics 6, 213-223.en_US
dc.identifier.urihttp://hdl.handle.net/1828/5421
dc.language.isoenen_US
dc.rights.tempAvailable to the World Wide Weben_US
dc.subjectEcological genomicsen_US
dc.subjectEctoparasiteen_US
dc.subjectHost-parasiteen_US
dc.subjectImmunityen_US
dc.subjectInflammationen_US
dc.subjectIronen_US
dc.subjectAbiotic stressen_US
dc.subjectSalmonen_US
dc.subjectAquacultureen_US
dc.subjectSea liceen_US
dc.subjectDrug resistanceen_US
dc.subjectTranscriptomicsen_US
dc.titleComparative responses of salmon to sea lice Lepeophtheirus salmonis infections, and lice responses to chemical and environmental stressorsen_US
dc.typeThesisen_US

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