Acute neurobehavioural changes following repeat mild traumatic brain injury

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dc.contributor.authorWortman, Ryan C
dc.contributor.supervisorChristie, Brian R.
dc.date.accessioned2017-05-01T15:29:53Z
dc.date.available2017-05-01T15:29:53Z
dc.date.copyright2017en_US
dc.date.issued2017-05-01
dc.degree.departmentProgram: Neuroscienceen_US
dc.degree.levelMaster of Science M.Sc.en_US
dc.description.abstractThere is increasing evidence that repeat mild traumatic brain injury (rmTBI) may result in cumulative and long-term symptoms, more pronounced behavioural deficits, and neurodegeneration. Children have a greater susceptibility to head injury and represent a significant at risk population for rmTBI, especially those that participate in contact sports. Despite this, there is a paucity of data on rmTBI pathophysiology in the juvenile brain. The current study utilizes a novel awake closed head injury (ACHI) model to deliver repeat injuries to fully conscious juvenile rats. The ACHI model avoids the potential confounds of anaesthesia, and facilitates the assessment of neurological function immediately after each impact. Results indicate that the ACHI model produces acute neurological deficits after each impact, and that repeat injury worsens outcomes. Behavioural testing identified transient anxiety-like behaviour and motor impairment in response to rmTBI. The functional impairments and affective behaviour were in the absence of tau protein pathology. This study represents the first investigation of the consequences of rmTBI on the juvenile brain using an awake model of brain injury.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.urihttp://hdl.handle.net/1828/8037
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectconcussionen_US
dc.subjectmild traumatic brain injuryen_US
dc.subjectbehaviouren_US
dc.subjectjuvenileen_US
dc.titleAcute neurobehavioural changes following repeat mild traumatic brain injuryen_US
dc.typeThesisen_US

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