Shaping the future of Leptospira serotyping

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dc.contributor.authorGiraud-Gatineau, Alexandre
dc.contributor.authorDagbo, Kouessi
dc.contributor.authorPětrošová, Helena
dc.contributor.authorWerts, Catherine
dc.contributor.authorVeyrier, Fréderic J.
dc.contributor.authorPicardeau, Mathieu
dc.date.accessioned2026-05-07T17:31:18Z
dc.date.available2026-05-07T17:31:18Z
dc.date.issued2025
dc.description.abstractLeptospirosis is a re-emerging zoonosis caused by a diverse range of pathogenic Leptospira, which are divided into species, serogroups and serovars. Although advances in genomics have recently refined species classification, serotyping, which is based on the antigenic variability of lipopolysaccharides O-antigens, still relies heavily on traditional and labour-intensive methods. In addition, the molecular basis of serovar diversity is not fully understood, which poses challenges for rapid and accurate serovar and/or serogroup identification. However, identification of serovars remains crucial for epidemiological studies, surveillance, diagnostics, understanding host–pathogen interactions and vaccine development. In this review, we assess current techniques for Leptospira serovar and serogroup identification and explore emerging DNA-based methodologies for serovar and serogroup prediction.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.description.sponsorshipThis research was supported by the Institut Pasteur, the National Institutes of Health grant P01 AI 168148 and Santé Publique France. F.V. received a Junior 1, Junior 2 and Senior Research Scholar salary award from the Fonds de Recherche du Québec – Santé. K.D. received a studentship from the Fondation Arbour. H.P. would like to acknowledge support from Genome British Columbia (GBC) and Genome Canada (365MET, 375MET and 374PRO) for The Metabolomics Innovation Centre (TMIC) and the BC Proteomics Centre, awarded to the Director of the University of Victoria Genome BC Proteomics Centre, David R. Goodlett.
dc.identifier.citationGiraud-Gatineau, A., Dagbo, K., P?trošová, H., Werts, C., Veyrier, F. J., & Picardeau, M. (2025). Shaping the future of Leptospira serotyping. Journal of Medical Microbiology, 74(9). https://doi.org/10.1099/jmm.0.002059
dc.identifier.urihttps://doi.org/10.1099/jmm.0.002059
dc.identifier.urihttps://hdl.handle.net/1828/23837
dc.language.isoen
dc.publisherJournal of Medical Microbiology
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdiagnosis
dc.subjectepidemiology
dc.subjectleptospirosis
dc.subjectserology
dc.subjectstrain typing
dc.subjectSexual and Reproductive Health and Rights (SRHR) Aspiration Research Cluster
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleShaping the future of Leptospira serotyping
dc.typeArticle

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