Combining induced pluripotent stem cells and fibrin matrices for spinal cord injury repair

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dc.contributor.authorMontgomery, Amy
dc.contributor.supervisorWillerth, Stephanie M
dc.date.accessioned2014-04-23T20:47:05Z
dc.date.available2014-04-23T20:47:05Z
dc.date.copyright2014en_US
dc.date.issued2014-04-23
dc.degree.departmentDepartment of Mechanical Engineering
dc.degree.levelMaster of Applied Science M.A.Sc.en_US
dc.description.abstractSpinal cord injuries result in permanent loss of motor function, leaving those affected with long term physical and financial burdens. Strategies for spinal cord injury repair must overcome unique challenges due to scar tissue that seals off the injury site, preventing regeneration. Tissue engineering can address these challenges with scaffolds that serve as cell- and drug-delivery tools, replacing damaged tissue while simultaneously addressing the inhibitory environment on a biochemical level. To advance this approach, the choice of cells, biomaterial matrix, and drug delivery system must be investigated and evaluated. This research seeks to evaluate (1) the behaviour of murine induced pluripotent stem cells in previously characterized 3D fibrin matrices; (2) the 3D fibrin matrix as a platform to support the differentiation of human induced pluripotent stem cells; and (3) the ability of an affinity-based drug delivery system to control the release of emerging spinal cord injury therapeutic, heat shock protein 70 from fibrin scaffolds.en_US
dc.description.proquestcode0541en_US
dc.description.proquestemailamy.lynn.montgomery@gmail.comen_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationMontgomery, Amy et al (2014). Combining protein-based biomaterials with stem cells for spinal cord injury repair. OA Stem Cells Jan 18;2(1):1.en_US
dc.identifier.bibliographicCitationKhadem Mohtaram, Nima et al (2013). Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors. Biomed. Mater. 8 022001.en_US
dc.identifier.urihttp://hdl.handle.net/1828/5272
dc.languageEnglisheng
dc.language.isoenen_US
dc.rights.tempAvailable to the World Wide Weben_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectinduced pluripotent stem cellsen_US
dc.subjectspinal cord injuryen_US
dc.subjectfibrinen_US
dc.subjectneural differentiationen_US
dc.subjectheat shock protein 70en_US
dc.subjecttissue engineeringen_US
dc.subjectbiomaterialsen_US
dc.titleCombining induced pluripotent stem cells and fibrin matrices for spinal cord injury repairen_US
dc.typeThesisen_US

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